阳离子抗菌肽的杀菌及抗药性机制的研究进展

摘要/Abstract

摘要： 阳离子抗菌肽是生物体抵御外源性病原微生物入侵而产生的一类小分子多肽, 广泛分布于生物体内,具有广谱抗菌活性,是生物体先天性免疫防御系统的重要组成部分。除了具有抗细菌功能外,还具有抗真菌、抗原虫、抗病毒及抑制肿瘤细胞等功能,并对正常的真核细胞毒性较低,是新一代抗生素的理想替代品,但是同抗生素一样,部分细菌也能对抗菌肽产生抗药性。作者将从阳离子抗菌肽的杀菌及抗药性机制等方面进行阐述。

关键词: 阳离子抗菌肽; 细菌; 杀菌机制; 耐药机制

Abstract: Cationic antimicrobial peptides were a class of small peptides with anti-extrogenous pathogen invasion. As an important component of congenital immune defense system against infections, they were widely distributed in vivo. It exhibited potent and broad-spectrum activities against both Gram-positive and Gram-negative bacteria, fungi, viruses, protozoa, and cancer cells,and normal eukaryotic cells with low toxicity. It was an ideal alternative to a new generation of antibiotics. However, the same as antibiotics, some bacteria were resistant to certain antimicrobial peptides. The antibacterial and drug-resistant mechanism of the cationic antimicrobial peptides were summarized in the article to provide certain reference.

Key words: cationic antimicrobial peptides; bacteria; antimicrobial mechanism; mechanisms of resistance

中图分类号:

洪军, 胡建业. 阳离子抗菌肽的杀菌及抗药性机制的研究进展[J]. , 2012, 39(11): 140-144.

HONG Jun, HU Jian-ye. Research Progress on Cationic Antimicrobial Peptides in Antibacterial and Drug-resistant Mechanism[J]. , 2012, 39(11): 140-144.

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