关键词: 山羊; 药代动力学; 伊维菌素; 阿苯达唑

Abstract: To investigate the pharmacokinetics of Ivermectin emulsion compound in vivo, and to provide the medical information for the veterinary clinical diagnosis, 7 goats as experimental models were selected, and each goat was given orally Ivermectin emulsion compound by dose of 0.1 mL/kg (Ivermectin 0.2 mg/kg, Albendazole 10 mg/kg). Blood samples were respectively taken 5 mL from Jugular vein at 0.5, 1, 2, 3, 4, 6, 8, 12, 16, 24, 36, 48 and 60 h after administration, then the serum were separated and stored at -20 ℃. High performance liquid chromatography (HPLC) method was used to detect serum drug level. The results showed that: ①The metabolism of Ivermectin in goat: the drug concentration was 0.112151 μg/mL after 0.5 h; the first peak time was 0.302702 μg/mL after 4 h, and the second peak time was both 0.258284 μg/mL after 16 h and 0.011118 μg/mL after 60 h. ②Albendazole metabolism in goats:the drug concentration was 0.049285 μg/mL after 0.5 h; the first peak time was 4.95283 μg/mL after 8 h, and the second peak time were both of 5.694551 μg/mL after 16 h and 0.06434 μg/mL after 60 h.The metabolized time of Ivermectin and Albendazole of Ivermectin emulsion compound in goat was very short, and the drug concentration in serum was not too low until 60 h.

Key words: goat; pharmacokinetics; Ivermectin; Albendazole