中国畜牧兽医 ›› 2022, Vol. 49 ›› Issue (10): 3746-3755.doi: 10.16431/j.cnki.1671-7236.2022.10.006
李勋胜1, 史婉婉1, 邢宝瑞1, 周珏1, 李春义2, 孙红梅1
收稿日期:
2022-04-26
出版日期:
2022-10-05
发布日期:
2022-09-30
通讯作者:
孙红梅,E-mail:Sunhongmei@caas.cn
作者简介:
李勋胜,E-mail:Lixunsheng18@outlook.com。
基金资助:
LI Xunsheng1, SHI Wanwan1, XING Baorui1, ZHOU Jue1, LI Chunyi2, SUN Hongmei1
Received:
2022-04-26
Online:
2022-10-05
Published:
2022-09-30
摘要: 半乳糖凝集素1(galectin-1,GAL-1)是一种分子质量约为14 ku的β-半乳糖苷结合蛋白,分布于许多不同类型的细胞和组织中,在细胞内外均具有广泛的生物学活性,参与调节多种生理病理过程。GAL-1以剂量依赖性和细胞特异性双向调控细胞增殖,通过血管内皮生长因子受体2(vascular endothelial growth factor receptor 2,VEGFR2)途径促进血管的生成,参与机体的免疫调节,诱导T细胞凋亡、抑制T细胞增殖和抗原递呈细胞活化等。此外,GAL-1被认为是多种类型肿瘤的标志物,肿瘤细胞通过分泌GAL-1促进肿瘤内的血管生成和自身免疫逃逸。鹿茸是指鹿科动物头部衍生的未骨化密生茸毛的幼角,也是在自然界哺乳动物中迄今为止发现的唯一可实现周期性完全再生的骨质附属器官。鹿茸的再生是基于鹿茸干细胞增殖的过程,GAL-1在鹿茸干细胞中表达,并且鹿茸的再生过程与GAL-1生物学功能息息相关。然而,GAL-1在鹿茸再生过程中所扮演的角色仍待深入研究。作者综述了GAL-1的结构、生物学功能及其在鹿茸再生过程中的作用,以期为GAL-1和鹿茸再生机制的研究带来新的启示。
中图分类号:
李勋胜, 史婉婉, 邢宝瑞, 周珏, 李春义, 孙红梅. 半乳糖凝集素1的生物学功能及其在鹿茸再生过程中的作用研究进展[J]. 中国畜牧兽医, 2022, 49(10): 3746-3755.
LI Xunsheng, SHI Wanwan, XING Baorui, ZHOU Jue, LI Chunyi, SUN Hongmei. Research Progress on the Biological Function of Galectin-1 and Its Role in Deer Antler Regeneration[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(10): 3746-3755.
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