中国畜牧兽医 ›› 2020, Vol. 47 ›› Issue (12): 4103-4118.doi: 10.16431/j.cnki.1671-7236.2020.12.035
马兴树1, 强慧勤2, 杨锴3
收稿日期:
2020-05-13
出版日期:
2020-12-20
发布日期:
2020-12-18
通讯作者:
杨锴
E-mail:kexing@kexingpharma.com
作者简介:
马兴树(1963-),男,河北张家口人,博士,教授,主要从事动物传染病防治及病原微生物分子生物学的教学与研究工作,E-mail:maxingshu@126.com
基金资助:
MA Xingshu1, QIANG Huiqin2, YANG Kai3
Received:
2020-05-13
Online:
2020-12-20
Published:
2020-12-18
摘要: 禽致病性大肠杆菌(avian pathogenic Escherichia coli,APEC)是导致不同日龄禽类局部和全身感染的重要病原菌,也是人肠外致病性大肠杆菌(extraintestinal pathogenic Escherichia coli,ExPEC)毒力基因的重要储存宿主或来源。为深入理解APEC的感染过程、致病机理、宿主免疫应答及遗传抵抗机制、评估药物和疫苗防治效果,研究者通过不同途径建立了多种评估APEC毒力的实验感染模型。根据所涉及的系统不同可分为呼吸系统、脉管系统、肌肉系统、皮肤系统、生殖系统、消化系统及鸡胚系统等。此外,尚有小鼠与大鼠感染试验及组织培养细胞和外植块感染试验等。作者重点介绍了不同APEC实验感染模型的建立、致病机制、宿主应答及应用。
中图分类号:
马兴树, 强慧勤, 杨锴. 禽致病性大肠杆菌实验感染模型研究进展[J]. 中国畜牧兽医, 2020, 47(12): 4103-4118.
MA Xingshu, QIANG Huiqin, YANG Kai. Advances on the Experimental Infectious Models of Avian Pathologenic Escherichia coli[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(12): 4103-4118.
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