同源异型框基因Prrx功能的研究进展

doi:10.16431/j.cnki.1671-7236.2017.02.042

摘要/Abstract

摘要：

同源异型框（homeobox，HoX）基因是具有较高遗传等级并能控制细胞分化和形态发育的重要基因。同源异型框基因主要在胚胎时期高度表达，对胚胎的发育、分化及对肢体结构和器官发育有重要影响。同源异型框基因Prrx主要包括3种，分别是Prrx1、Prrx2和Prrx3。Prrx基因家族在人和鼠的腭裂、颌骨、四肢、胫腓骨的组织发育中有重要作用，并与大脑、脊髓、神经、心脏等器官的发育密切相关。其中Prrx1和Prrx2基因主要参与胚胎中骨骼和心血管系统的发育，如四肢、颅面、软骨和动脉管。Prrx3基因主要参与胚胎中骨、软骨、大脑、脊髓等的发育。文章针对Prrx基因的功能进行概述，以期为这些基因功能的研究及相关疾病的防控提供一定的参考。

关键词: 同源异型框; Prrx基因; 生长发育

Abstract:

The homeobox (HoX) gene that controls cell differentiation and morphological development is an important gene having highly genetic level. These genes highly express in the embryonic period and affect the embryonic development and differentiation and control the development of body structure and organs. The homeobox gene Prrx includes three types, Prrx1, Prrx2 and Prrx3, this family gene plays an important role in the development of cleft palate, jaw, extremities, tibia and fibula in human and mouse, and is also closely related to the development of the brain, spinal cord, nerve, heart and other organs. The Prrx1 and Prrx2 are mainly involved in the development of bone and cardiovascular system in embryo, such as limb, craniofacial, cartilage and arteries, and Prrx3 is mainly involved in the development of embryonic cartilage, bone, brain, spinal cord and so on. This paper reviewed the functions of Prrx gene, so as to provide certain references for research on the gene functions and prevention and control of related diseases.

Key words: homeobox; Prrx gene; growth and development

中图分类号:

徐小桐, 张昕, 杜娟, 杨晓农. 同源异型框基因Prrx功能的研究进展[J]. 《中国畜牧兽医》, 2017, 44(2): 607-612.

XU Xiao-tong, ZHANG Xin, DU Juan, YANG Xiao-nong. Research Progress on Functions of Homeobox Gene Prrx[J]. , 2017, 44(2): 607-612.

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