IGF2基因表达调控及其遗传变异在动物生长发育中的研究进展

doi:10.16431/j.cnki.1671-7236.2020.06.024

摘要/Abstract

摘要： 胰岛素样生长因子2（insulin-like growth factor 2，IGF2）作为胰岛素类激素家族中重要成员之一，广泛参与机体众多生理代谢过程，在癌症发生、神经调节、糖代谢疾病、骨质疏松、肌肉发育和脂肪沉积等方面具有重要的作用，其功能行使主要通过与受体IGF1R和IGF2R结合或与胰岛素样生长因子结合蛋白IGFBPs和IGF2BPs竞争性结合发挥功能。鉴于IGF2基因在肌肉发育和脂肪沉积中的重要作用，发掘IGF2基因相关分子标记并解析其内在调控机理，在畜牧生产中具有重要的意义。研究发现，众多IGF2基因遗传变异与动物的生长发育之间存在显著相关关系，其可能通过影响IGF2基因印记、甲基化状态、转录因子结合或miRNA靶向结合型转录后调控等方式发挥作用。因此，文章综述了IGF2基因表达调控模式，包括IGF2与其受体的调控关系，基因印记与miRNA参与的表观遗传调控，转录因子对其的调节作用，遗传变异等方面的内容，以期为IGF2基因在动物生长发育调控相关研究中提供相应的借鉴，为分子育种提供有效线索。

关键词: IGF2基因; 生长发育; 转录因子; 遗传变异

Abstract: Insulin-like growth factor 2(IGF2),one of the insulin-like hormone family,widely involved in many physiological and metabolic processes of the body,which has an important role in cancer,neuroregulation,metabolic disease,osteoporosis,muscle development and lipidosis.IGF2 functions mainly through competitive binding to the IGF1R,IGF2R or IGF2BPs.Base on the IGF2 plays an important role in musle develop and lipidosis,it makes sense to mine molecular markers of IGF2.Furthermore,the internal regulation mechanism of IGF2 in livestock production was further analyzed.It was found that there was a significant correlation between the genetic variation of IGF2 gene and animal development.Genetic variation functions by affecting IGF2 gene imprinting,methylation,transcription factors binding or post-transcriptional regulation due to miRNA targeting binding.Therefore,this paper focused on the research progress of IGF2 gene expression regulation,gene imprinting,and epigenetic regulation about miRNA,in order to provide relevant reference for the study of IGF2 gene in the regulation of animal growth and development,and provide effective clues for molecular breeding in animal husbandry.

Key words: IGF2 gene; growth and development; transcription factor; heritable variation

中图分类号:

S811.3

赵海东, 邬明丽, 陈平博, 韦燕佩, 王淑辉, 孙秀柱. IGF2基因表达调控及其遗传变异在动物生长发育中的研究进展[J]. 中国畜牧兽医, 2020, 47(6): 1844-1852.

ZHAO Haidong, WU Mingli, CHEN Pingbo, WEI Yanpei, WANG Shuhui, SUN Xiuzhu. Research Progress of IGF2 Gene Expression Regulation and Its Genetic Variation in Animal Growth and Development[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(6): 1844-1852.

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