全基因组选择信号检测方法在家畜研究中的应用进展

doi:10.16431/j.cnki.1671-7236.2016.06.038

摘要/Abstract

摘要： 长期的自然和人为选择使家畜品种经济性状得到了显著改善,其相关的基因组区域也发生了特定遗传变异。随着时间的推移部分基因多态性已经下降或消失,而在群体中保留包含单一单倍型的多个基因。这种基因组上特定区域基因多态性频率的变异被称为选择信号。识别选择信号可以提供家畜驯化机制并进一步揭示表型相关的基因变异。目前,高密度SNP芯片及大规模重测序技术已成功应用于家畜选择信号鉴定研究。全基因组选择信号检测方法有等位基因频率检测法、连锁不平衡检测法和群体分化分析法。作者综述了全基因组范围内选择信号检测方法及其在家畜研究中的应用进展,为从事家畜育种及生物进化研究人员提供参考。

关键词: 家畜; 驯化; 选择信号; 检测方法

Abstract: The economic traits of livestock has been significantly improved due to long-term under natural and artificial selection,and the specific variation characterizations emerged from the selected genome regions.As time goes on,the some polymorphism frequency of gene has dropped or disappeared,and keep in a group contains a single haploid type of multiple genes.This frequency variation of gene in specific region on the genomes is called the signatures of selection.Identifying signatures of selection can provide a straightforward insight into the mechaism of domestication and further uncover the casual genes related to the phenotypic variation.The high density SNP chips and large scale resequencing technology have been successfully applied to genomic selection signature in livestock breeds.The methods to detect selection signatures can be classed into three categories:Site frequency spectrum based methods,haplotyped based methods and population differentiation based methods.In the present article,we summarized the methods of selection signature detection and development and application of genomic selection signature methods in livestock.It will provide useful information for researchers working with breeding and evolutionary biology.

Key words: livestock; domestication; selective signature; methods of detection

中图分类号:

S813.3

阿地力江·卡德尔, 刘雪雪, 杨敏, 玛哈巴·肉孜, 蒋琳, 马月辉. 全基因组选择信号检测方法在家畜研究中的应用进展[J]. , 2016, 43(6): 1641-1646.

ADILJAN Kader, LIU Xue-xue, YANG Min, MARHABA Ruzi, JIANG Lin, MA Yue-hui. Development and Application of Genomic Selection Signature Methods in Livestock Species[J]. , 2016, 43(6): 1641-1646.

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