线粒体未折叠蛋白反应的研究进展

doi:10.16431/j.cnki.1671-7236.2015.07.024

›› 2015, Vol. 42 ›› Issue (7): 1787-1792.doi: 10.16431/j.cnki.1671-7236.2015.07.024

线粒体未折叠蛋白反应的研究进展

李帅峰, 胡林, 汪加兴, 张淑君

华中农业大学动物科学技术学院, 农业动物遗传育种与繁殖教育部重点实验室, 武汉 430070

收稿日期:2014-12-29 出版日期:2015-07-20 发布日期:2015-07-23
通讯作者: 张淑君 E-mail:sjxiaozhang@mail.hzau.edu.cn
作者简介:李帅峰(1987-),女,河南汝州人,博士,从事病毒感染与细胞自噬及线粒体自噬等相关研究,E-mail:shuaifeng625li@webmail.hzau.edu.cn
基金资助:
国家自然科学基金(31272427);欧盟FP7项目(PIIF-GA-2012-328205、PIIFR-GA-2012-912205 和 FP7-KBBE-2013-7-613689)

Research Progress on Mitochondrial Unfolded Protein Response

LI Shuai-feng, HU Lin, WANG Jia-xing, ZHANG Shu-jun

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China

Received:2014-12-29 Online:2015-07-20 Published:2015-07-23

摘要/Abstract

摘要： 线粒体是细胞内重要的细胞器之一,调控多种细胞内信号通路,然而环境应激会导致线粒体堆积并产生大量错误折叠或未折叠蛋白,造成线粒体功能紊乱。目前研究发现多种由线粒体到细胞核的信号传导通路能够缓解线粒体应激反应,维持线粒体的正常功能状态。本综述就酿酒酵母中的逆行反应,哺乳动物细胞和线虫中的线粒体未折叠蛋白的分子机制及线粒体未折叠蛋白反应与线粒体自噬、天然免疫的相互关系进行重点介绍。

关键词: 线粒体; 逆行反应; 未折叠蛋白反应; 线粒体自噬

Abstract: Mitochondria,as one of important intracellular organelles,regulates many intracellular signaling pathways,but environmental stress can cause accumulation of large amounts of misfolded or unfolded proteins,resulting in mitochondrial dysfunction.Current studies have revealed that a variety forms of signaling pathway from mitochondria to nucleus which can alleviate mitochondrial stress reaction and maintain mitochondrial homeostasis.In this paper,we will lay emphasis on that the molecular mechanisms of retrograde reactions in Saccharomyces cerevisiae,mitochondrial unfolded protein response in mammalian cells and C.elegans,and the interaction between mitochondrial unfolded protein response and mitophagy,innate immunity.

Key words: mitochondria; retrograde response; unfolded protein response; mitophagy

中图分类号:

Q244

李帅峰, 胡林, 汪加兴, 张淑君. 线粒体未折叠蛋白反应的研究进展[J]. , 2015, 42(7): 1787-1792.

LI Shuai-feng, HU Lin, WANG Jia-xing, ZHANG Shu-jun. Research Progress on Mitochondrial Unfolded Protein Response[J]. , 2015, 42(7): 1787-1792.

参考文献

[1] Pagliarini D J,Calvo S E,Chang B,et al.A mitochondrial protein compendium elucidates complex 1 disease biology[J].Cell,2008,134(1):112-123.
[2] Zhao Q,Wang J,Levichkin I V,et al.A mitochondrial specific stress response in mammalian cells[J].The EMBO Journal,2002,21(17):4411-4419.
[3] Butow R A,Avadhani N G.Mitochondrial signaling: The retrograde response[J].Molecular Cell,2004,14:1-15.
[4] Sekito T,Thornton J,Butow R A.Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p[J].Molecular Billogy of the Cell,2000,11:2103-2115.
[5] Liu Z,Sekito T,Śpírek M,et al.Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p[J].Molecular Cell,2003,12:401-411.
[6] Horibe T,Hoogenraad N J.The Chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response[J].PLoS One,2007,2(9):e835.
[7] Papa L,Germain D.Estrogen receptor mediates a distinct mitochondrial unforded protein response[J].Journal of Cell Science,2011,124:1396-1402.
[8] Papa L,Germain D.SirT3 regulates the mitochondrial unfolded protein response[J].Molecular and Cellular Biology,2014,34(4):699-710.
[9] Pellegrino M W,Nargund A M,Haynes C M.Signaling the mitochondrial unfolded protein response[J].Biochimica et Biophysica Acta,2013,1833:410-416.
[10] Yoneda T,Benedetti C,Urano F,et al.Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones[J].Journal of Cell Science,2004,117(18):4055-4066.
[11] Chacinska A,Koehler C M,Milenkovic D,et al.Importing mitochondrial proteins: Machineries and mechanisms[J].Cell,2009,138:628-644.
[12] Nargund A M,Pellegrino M W,Fiorese C J,et al.Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation[J].Science,2012,337:587-591.
[13] Haynes C M,Petrova K,Benedetti C,et al.ClpP mediates activation of a mitochondrial unfold protein response in C.elegans[J].Developmental Cell,2007,13:467-480.
[14] Haynes C M,Yang Y,Blais S P,et al.The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C.elegans[J].Molecular Cell,2010,37:529-540.
[15] Mouchiroud L,Houtkooper R H,Moullan N,et al.The NAD⁺/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling[J].Cell,2013,154:430-441.
[16] Mottis A,Jovaisaite V,Auwerx J.The mitochondrial unfolded protein response in mammalian physiology[J].Mamm Genome,2014,25:424-433.
[17] Vives-Bauza C,Zhou C,Huang Y,et al.PINK1-dependent recruitment of Parkin to mitochondria in mitophagy[J].PNAS,2010,107(1):378-383.
[18] Narendra D,Tanaka A,Suen D F,et al.Parkin is recruited selectively to impaired mitochondria and promotes their autophagy[J].The Journal of Cell Biology,2008,183(5):795-803.
[19] Suen D F,Narendra D P,Tanaka A,et al.Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells[J].PNAS,2010,107(26):11835-11840.
[20] Jin S M,Youle R J.The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria[J].Autophagy,2013,9(11):1750-1757.
[21] Arnoult D,Soares F,Tattoli I,et al.Mitochondria in innate immunity[J].EMBO Report,2012,12(9):901-910.
[22] Sena L A,Li S,Jairaman A,et al.Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling[J].Immunity,2013,38:225-236.
[23] Pellegrino M W,Nargund A M,Kirienko N V,et al.Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection[J].Nature,2014,516(7531):414-417.
[24] Rath E,Berger E,Messlik A,et al.Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation[J].Gut,2012,61:1269-1278.
[25] Lu C,Cortopassi G.Frataxin knockdown causes loss of cytoplasmic iron-sulfur cluster functions,redox alterations and induction of heme transcripts[J].Archives of Biochemistry and Bilphysics,2007,457:111-122.
[26] Haynes C M,Fiorese C J,Lin Y F.Evaluating and responding to mitochondrial dysfunction: The mitochondrial unfolded-protein response and beyond[J].Trends in Cell Biology,2013,23(7):311-318.

线粒体未折叠蛋白反应的研究进展

Research Progress on Mitochondrial Unfolded Protein Response

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