视黄酸诱导基因-Ⅰ在家禽天然免疫应答中作用的研究进展

doi:10.16431/j.cnki.1671-7236.2018.12.021

Abstract

Abstract:

The innate immune response of poultry plays a key role in protecting the host from viral infections.Retinoic acid inducible gene-Ⅰ (RIG-Ⅰ) is used as a class of cytoplasmic internal recognition receptor of viral double-stranded RNA which is closely related to the natural immune response.It can monitor viral RNA in the cytoplasm by RNA ligand binding to pathogen-associated molecular patterns,and that process can activate RIG-Ⅰ and downstream mitochondrial antiviral signaling protein (MAVS),eventually leading to the activation of interferon regulatory factor (IRF3/7) and NF-κB,induce the production of type Ⅰ interferon and other immune cytokines,and then the cells make a corresponding anti-viral natural immune response.However,due to the lack of RIG-Ⅰ gene in chickens,the current researches are most to transfer RIG-Ⅰ gene from duck or geese source to chicken fibroblasts (DF-1) to study whether RIG-Ⅰ gene has immune function in chicken infected avian viruses.This article describes the expression of RIG-Ⅰ in poultry and its mediated antiviral innate immune signaling pathway,outlines the research status of antiviral effects of RIG-Ⅰ in poultry to provide references in the study of infection and immune system of poultry and the development of new anti-virus vaccines and immune adjuvants.

Key words: RIG-Ⅰ; poultry; natural immune response; antiviral

CLC Number:

S852.4

LI Xuefeng, REN Mengting, XU Liwen, WANG Fangfang. Research Progress on Role of Retinoic Acid Inducible Gene-Ⅰ in Innate Immune Response of Poultry[J]. , 2018, 45(12): 3479-3485.

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Research Progress on Role of Retinoic Acid Inducible Gene-Ⅰ in Innate Immune Response of Poultry

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