氟苯尼考-羟丙基-β-环糊精包合物的研制

doi:10.16431/j.cnki.1671-7236.2017.06.039

Abstract

Abstract:

Florfenicol-hydroxypropyl-β-cyclodextrin was prepared by colloid mill technique using orthogonal experiment technology to improve its solubility. The inclusion rate and getting ratio of the complex were taken as indexes to analyze the effect. The optimum preparation procedure was the proportion of 1:1 for HP-β-CD to florfenicol, the concentration was 6 mg/mL and the time was 1 h. Its structure was proved by DSC and IR, which suggested that the florfenicol was wrapped by HP-β-CD. The inclusion rate was 83.74% and the getting ratio was 98.48%. The solubility of florfenicol was increased from 1.25 mg/mL to 40.76 mg/mL.Thus, it showed that the process was suitable for batch preparation of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex.

Key words: florfenicol; hydroxypropyl-β-cyclodextrin; inclusion complex; solubility; orthogonal experiment

CLC Number:

S859.5

YANG Bao-ting, WANG Geng-nan, HUANG Kang-dong, LIU Jing, LIU Ju-xiang. Preparation and Identification of Florfenicol-hydroxypropyl-β-cyclodextrin[J]. , 2017, 44(6): 1854-1860.

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Preparation and Identification of Florfenicol-hydroxypropyl-β-cyclodextrin

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