饱和水溶液法制备莫能菌素-β-环糊精包合物的研究

doi:10.16431/j.cnki.1671-7236.2017.01.041

Abstract

Abstract:

To study the preparation technology of inclusion compound carrying monensin, monensin was encapsulated with β-cyclodextrin using saturated water solution. The phase identification of inclusion compound was examed by infra-red spectrum (IR).Based on a comprehensive evaluation of inclusion efficiency, the optimal formulation and process conditions of inclusion compound carrying monensin were determined by orthogonal design methods.IR result showed that inclusion compound carrying monensin was formed;The best optimum of the preparation technology were as follows:The proportion of the quality of β-cyclodextrin and monensin was 3:1,the temperature of inclusion was 40℃,and the time of inclusion was 1.5 h. The inclusion rate was 57.54%.This preparation technology was feasible,and enlarged the use of monensin. The study laid a foundation for improvement about dosage form of monensin.

Key words: inclusion compound of monensin; β-cyclodextrin; saturated water solution method; IR; inclusion rate

CLC Number:

R944.2

YANG Xiao-yun, FU Li-na, CHEN Hong-xuan, LI Jian-mei, ZHANG Cui-li, XIN Jian-hong. Development of Preparation of Inclusion Compound Carrying Monensin Entrapped by Beta-Cyclodextrin Adopted by Saturated Water Solution[J]. , 2017, 44(1): 289-295.

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Development of Preparation of Inclusion Compound Carrying Monensin Entrapped by Beta-Cyclodextrin Adopted by Saturated Water Solution

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