抗菌增效剂药动学与残留消除研究进展

doi:10.16431/j.cnki.1671-7236.2016.12.009

Abstract

Abstract:

Antibacterial synergist can enhance the antibacterial activity of the antibiotics, reduce bacterial resistance and improve treatment effect. Pharmacokinetic study is to develop dosage regimen and evaluate efficacy in clinical.Elimination of residual study can understand drug residual target tissue and residual marker to formulate appropriate withdraw time. This review briefly describes the aditoprim, trimethoprim,diaveridine of three kinds of antibacterial synergist pharmacokinetic and residue elimination rule, emphatically when contrast aditoprim to trimethoprim in the pharmacokinetic parameters of different animals. We can conclude aditoprim with longer elimination half-life and larger apparent volume of distribution, and trimethoprim elimination half-life is different in different animals, diaveridine is often used as intestinal antibacterial synergist. Recently researchers always use high performance liquid chromatography (HPLC) method or chromatographic combination method to study antibacterial synergist on pharmacokinetics and residues elimination research, it shows that the method has good specificity and high sensitivity. Currently due to the irrational use even abuse of antibiotics leading to drug failure and bacterial drug resistance problems, the presence of the antibacterial synergist for solving this problem provide a new direction, and three kinds of antibacterial synergist in different animals pharmacokinetic and residues elimination research is helpful to understand various kinds of drugs commonalities and differences in different animals, in order to find problems of this kind of drug in clinical using and continuously perfect applications of antibacterial synergist in clinical.

Key words: antibacterial synerists; aditoprim; trimethoprim; diaveridine; pharmacokinetics; elimination of residual; analytical method

CLC Number:

S859.7

SUN Ling-ling, YUAN Zong-hui, LI Mei, HUANG Ling-li. Research Progress on Pharmacokinetics and Residue Elimination of Antibacterial Synergist[J]. , 2016, 43(12): 3141-3148.

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Research Progress on Pharmacokinetics and Residue Elimination of Antibacterial Synergist

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