四次跨膜蛋白CD81的研究现状

doi:10.16431/j.cnki.1671-7236.2016.05.024

Abstract

Abstract: Tetraspanins with special four-times acrossing membrane structure can contact outer, intrinsic membrane and transmembrane proteins, which forms a channel to connect the internal and external membrane signal.CD81, as one member of Tetraspanins, has a variety of biological activities and is widely dispersed and participates in the organism physiological responses.CD81 plays an important role in many cell process, and is closely related to the pathogenesis of many human diseases, and so widely watched.But the molecular structure, space conformation and physiological mechanisms of CD81 are still not entirely clear.We still need to do further research and discussion, especially, the comprehensively understanding of precise role of CD81 in the process of HCV into a host cell, it is vital for clinical application.This article would focus on the research progresses of molecular structure and biochemical characteristics, cell fusion effect, the virus-identified mechanism, the role in the immune system and clinical application on CD81.In summary, clarifing the function and role of CD81 is important to study the clinical pathogenesis and treatment of various diseases.

Key words: CD81; cell fusion; immune; biomarker; virus

CLC Number:

SHI Zhen-dan, Wuliyasu, Wuyahan, Ailungaowa, MO Li-mei, Zhamuga, Wuyunsiqin, ZHANG Tie-jia, Narenhua. Current Research Status of Tetraspanins CD81[J]. , 2016, 43(5): 1277-1284.

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Current Research Status of Tetraspanins CD81

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