Abstract: To explore the therapeutic effect of Humulus scandens alcohol extract on secretory diarrhea in mice,we used lavage of senna to produce diarrhea mice mode.The mental state,body weight,colon intestinal wall thickness and histopathological changes were observed daily during the experiment period and the disease activity index was detected to evaluated therapeutic action of Humulus scandens alcohol extract on diarrhea.The results showed that compared with model group,the treatment group had significant effects on metal state,body weight and small intestinal villus recoveries;Compared with model group,body weight of treatment group had a rising trend but still couldn't reach the normal level.The DAI of treatment group decreased compared with model grope,there was no significant difference between blank group and treatment group (P>0.05).Compared with model group,intestinal wall thickness of treatment group were significant differences (P<0.05),the treatment effect was remarkable.Histological examination showed that in blank group,small intestinal villus was neatly,the hierarchical structure was clear,and there was no small vessel hyperemia and no villous intestinal edema.While small intestinal villus of model group disordered,most of the villus fell off,there was inflammation exudation on the surface of villi,villous edema and congestion of small blood vessels.Compared with model group,symptoms of treatment group significantly changed,which showed greatly reduced cell inflammatory exudation,there was no obvious edema and congestion in villi interstitial,small intestinal structure was roughly the same as normal tissue,the treatment effect was obvious.Humulus scandens alcohol extract had significant therapeutic effect on diarrhea in mice,and could provide a theoretical basis for the treatment of secretory diarrhea.

Key words: Humulus scandens alcohol extract; diarrhea; mice