Abstract: To study the genetic variation of the SCF gene CDS in different species, the genetic diversity of the CDS of SCF gene sequences from Capra hircus, Ovis aries, Bos taurus, Ceratotherium simum, Sus scrofa, Orcinus orca, Equus caballus, Mustela putorius furo, Homo sapiens, Sorex araneus, Heterocephalus glaber, Rattus norvegicus, Chinchilla lanigera, Mus musculus and Octodon degus were analyzed using the method of bioinformatics. The characteristics of composition of nucleic acid sequences and amino acid sequences, leader peptides, signal peptide, trans-membrane topological structure and the secondary structure were also analyzed, and some of the foci of intense investigation on the function of SCF were reviewed. The results showed that a total of 294 polymorphic sites were detected from 55 sequences of 15 species, from which 36 hapolotypes were sorted. The genetic diversity of the SCF gene CDS was rich among species. The theoretical isoelectric point of the sequences was widespread, most of the peptide chains were acidic, hydrophilic,with the N-terminal signal peptide and without leading peptide. Soluble peptide had no transmembrane domain, while transmembrane type had a 23 amino acid long transmembrane domain. The mainly secondary structures of these proteins were α-helix, disorderly curly, extended chain and β-corner.

Key words: specie; SCF gene; bioinformatics analysis