头孢维星研究进展

Abstract

Abstract: Cefovecin is a long-acting, third-generation cephalosporin antibiotic，and has good pharmacokinetic characteristics．It can be quickly absorbed，reached the Cmax, and be slowly eliminated．Moreover，cefovecin is a new extended-spectrum semisynthetic cephalosporin with a single injection providing a complete 14-day course of therapy．Cefovecin can be extensively used in veterinary clinic．This review details its newest research status，mechanism of action，antibacterial activities in vitro and in vivo, and clinical applications.

Key words: cefovecin; antibacterial activity; pharmacokinetics; clinical applications

SONG Fu-jie, LIU Ming-chun, FU Te. Reaserch Progress on Cefovecin[J]. .

References

1 Bakker J, Thuesen L R, Braskamp G, et al. Single subcutaneous dosing of cefovecin in rhesus monkeys (Macaca mulatta): A pharmacokinetic study［Ｊ］. J Vet Pharmacol Ther, 2011, 34(5): 464～468
2 Iyori K, Toyoda Y, Ide K.Usefulness of cefovecin disk-diffusion test for predicting mecA gene-containing strains of Staphylococcus pseudintermedius and clinical efficacy of cefovecin in dogs with superficial pyoderma［J］. Vet Dermatol, 2013, 24(1): 162～167.
3 Kano R, Hyuga A, Matsumoto J.Feline demodicosis caused by an unnamed species［J］. Res Vet Sci, 2012, 92(2): 257～258
4 Lawrence M, Kukanich K, Kukanich B.Effect of cefovecin on the fecal flora of healthy dogs［J］. Vet J, 2013, 20: 1090～1096.
5 Murphy C P, Reid-Smith R J, Boerlin P.Out-patient antimicrobial drug use in dogs and cats for new disease events from community companion animal practices in Ontario［J］. Can Vet J, 2012, 53(3): 291～298.
6 Papp R, Popovic A, Kelly N.Pharmacokinetics of cefovecin in squirrel monkey (Saimiri sciureus), rhesus macaques (Macaca mulatta), and cynomolgus macaques (Macaca fascicularis)［J］. J Am Assoc Lab Anim Sci, 2010, 49(6): 805～808.
7 Passmore C A, Sherington J, Stegemann M R.Efficacy and safety of cefovecin for the treatment of urinary tract infections in cats［J］. Small Anim Pract, 2008, 49(6): 295～301.
8 Raabe B M, Lovaglio J.Grover GS pharmacokinetics of cefovecin in cynomolgus macaques (Macaca fascicularis), olive baboons (Papio anubis), and rhesus macaques (Macaca mulatta)［J］. Am Assoc Lab Anim Sci, 2011, 50(3): 389～395.
9 Silva R O, D’elia M L, de Magalhes Soares D F.Clostridium difficile-associated diarrhea in an ocelot (Leopardus pardalis)［J］. Anaerobe, 2013, 20: 82～84.
10 Six R, Cherni J, Chesebrough R.Efficacy and safety of cefovecin in treating bacterial folliculitis, abscesses, or infected wounds in dogs［J］. Am Vet Med Assoc, 2008, 233(3): 433～439.
11 Six R, Cleaver D M, Lindeman C J.Effectiveness and safety of cefovecin sodium, an extended-spectrum injectable cephalosporin, in the treatment of cats with abscesses and infected wounds［J］. Am Vet Med Assoc, 2009, 234(1): 81～87.
12 Steeil J, Schumacher J, Seibert R.Cefovecin (convenia) for the treatment of septic peritonitis in a female lion (Panthera leo) ［J］. Zoo Wildl Med, 2012, 43(3): 678～681.
13 Stegemann M R, Passmore C A.Antimicrobial activity and spectrum of cefovecin, a newextended-spectrum cephalosporin, against pathogens collected from dogs and cats in Europe and North America［J］. Antimicrob Agents Chemother Vet Dermatol, 2006a, 50(7): 2286～2292.
14 Stegemann M R, Sherington J, Blanchflower S.Pharmacokinetics and pharmacodynamics of cefovecin in dogs［J］. Vet Pharmacol Ther, 2006b, 29(6): 501～511.
15 Stegemann M R, Sherington J.Pharmacokinetics of cefovecin in cats［J］. Vet Pharmacol Ther, 2006c, 29(6): 513～524.
16 Thuesen L R, Bertelsen M F, Brimer L.Selected pharmacokinetic parameters for cefovec in in hens and green iguanas［J］. Vet Pharmacol Ther, 2009, 32(6): 613～617.
17 Van Vlaenderen I, Nautrup B P, Gasper S M.Estimation of the clinical and economic consequences of non-compliance with antimicrobial treatment of canine skin infections［J］. Prev Vet Med, 2011, 99(2～4): 201～210.
18 Westermeyer R R, Roy A F, Mitchell M S.In vitro comparison of Staphylococcus pseudintermedius susceptibility to common cephalosporins used in dogs［J］. Vet Ther, 2010, 11(3): 1～9.

[1]	YANG Yuxin, ZHAO Fuhua, LIU Yu, QIU Jicheng, CAO Yuying, ZHANG Lu, BAI Runian, WANG Jianzhong, CAO Xingyuan. Pharmacokinetics and Bioequivalence of Two Cephalexin Formulations in Beagle Dogs [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(1): 386-394.
[2]	ZHANG Le, ZHANG Guangfeng, ZHU Chongmiao, WU Zhi, ZHU Shanyuan, YU Shenglan, FENG Qi, XING Xiaoling, ZHAO Qiannan. Study on Pharmacokinetics of Cyclodextrin-encapsulated Flufenicol in Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(6): 1934-1941.
[3]	HAN Yiqing, JI Xun, CHEN Chunqin, LIU Mingjiang, LI Jingui. Study on the Metabolism of Artemisinin in Chickens by LC-MS/MS [J]. China Animal Husbandry and Veterinary Medicine, 2019, 46(9): 2778-2786.
[4]	JIANG Zhihui, ZHANG Jingmiao, QU Yicheng, ZHANG Shouquan, CHANG Xuemei, GUO Xiao. Effect of Essential Oil from Artemisia vulgaris on CYP450 Isoforms Activity and Expression [J]. China Animal Husbandry and Veterinary Medicine, 2019, 46(11): 3440-3448.
[5]	LI Mei, SUN Lingling, YUAN Zonghui, HUANG Lingli. Research Progress on Veterinary Cephalosporins [J]. , 2018, 45(7): 1978-1989.
[6]	LI Jiao, LI Qingshan, XU Fengbo. Research Progress of Moxidectin in Animal Husbandry [J]. , 2018, 45(12): 3587-3593.
[7]	HAO Bao-cheng, QUAN Xiao-di, YE Yong-li, GAO Xu-dong, HUANG Xin, WANG Xue-hong, LIU Jian-zhi, WANG Bao-hai, LIANG Jian-ping. Study on Pharmacokinetics of Compound Traditional Chinese Medicine Preparation for Locoweed Detoxication [J]. , 2016, 43(6): 1550-1556.
[8]	SUN Ling-ling, YUAN Zong-hui, LI Mei, HUANG Ling-li. Research Progress on Pharmacokinetics and Residue Elimination of Antibacterial Synergist [J]. , 2016, 43(12): 3141-3148.
[9]	QUAN Xiao-di,HAO Bao-cheng,WANG Xue-hong,LIU Jian-zhi,WANG Bao-hai,LU Chao,XUE Hui-wen,LIANG Jian-ping. Study on Pharmacokinetics of Sukang Detoxification Oral Liquid in the Experimental Rats [J]. , 2014, 41(2): 129-135.
[10]	HE Xiang-lai, CHEN Xiao-lan. Study on Pharmacokinetics and Bioavailabilities of Cefquinome Sulfate in Ducks [J]. , 2013, 40(12): 95-98.
[11]	LI Hai-qin, CHEN Yun, ZHU Hua-jun, YAN Cheng, YUAN Xiao-qi, JIA Xue-xia, TANG Zhao-xin. Pharmacokinetics of the Pour-on Preparation of Doramectin in Dogs [J]. , 2012, 39(6): 156-160.
[12]	WANG Ying-ying;FANG Bing-hu;FAN Wei-da;Wang Lin. Pharmacokinetics of Quinocetone and its Major Metabolites in Swines [J]. , 2012, 39(5): 213-216.
[13]	ZHAO Lei-lei;YANG Juan;LIU Yi-ming;LI Peng-fei;WANG Zhong-jie;SU Dan;LI Xiu-bo. Research Progress in Animal-specific Antiprotozoal Drug Imidocarb [J]. , 2012, 39(2): 151-155.
[14]	ZHAN Da-wei, NIU Chun, YAN Ke-song, LI Jie, XU Chen, LIU Jin-yi. Study on Skin Region Pharmacokinetics of Recombinant Human Interferon α1b Spray [J]. , 2012, 39(10): 163-165.
[15]	WANG Lin;DING Huan-zhong. Application of Physiological Model in Veterinary Pharmacokinetic Study [J]. , 2011, 38(3): 47-50.

Reaserch Progress on Cefovecin

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments