奶牛乳糖合成及泌乳相关基因和细胞信号通路的研究进展

Abstract

Abstract: Lactose is a special component of milk and is closely related to milk yield. The factors of influencing lactose synthesis are extensive. The paper reviews the related genes and cell signaling pathways, including glucose transporters, intracellular catalytic lactose synthesis enzymes, hormones (insulin, prolactin, growth hormone, leptin, glucocorticoid ), cell factors(IGF-Ⅰ,IGF-Ⅱ,EGF) and its main cell signal transduction pathway.

Key words: lactose; glucose transporters; insulin-like growth factor; growth hormone; prolactin; cell signal pathways

CLC Number:

S852.2

LI Wen-qing, WANG Jia-qi, NAN Xue-mei, SUN Peng. Research Progress on Genes and Signal Pathways Associated with Lactose Synthesis and Lactation in Dairy Cows[J]. , 2012, 39(11): 104-110.

References

1 王海燕. 子宫内膜催乳素功能及信号转导机制[J]. 国外医学:妇产科学分册, 2003, 30(6):340~343.
2 宋舟,张立艳,董海兵,等. JAK-STAT信号通路研究进展[J].中国畜牧兽医,2012,39(6): 128~132.
3 李蔚辉,魏学鑫. 糖皮质激素的信号转导系统[J].亚太传统医药,2007,12(3):21~24.
4 迟素敏.内分泌生理学[M]. 西安:第四军医大学出版社, 2006.
5 邹思湘,李庆章. 动物生物化学[M]. 第4版. 北京:中国农业出版社, 2005.
6 胡晨,陈彬,王越,等. 乳腺癌中胰岛素样生长因子信号途径及其抑制剂研究[J]. 生命的化学,2009,29(6):907~911.
7 Accornero P, Martignani E, Macchi E, et al. Hepatocyte growth factor exerts multiple biological functions on bovine mammary epithelial cells[J]. J Dairy Sci,2007,90(9):4289~4296.
8 Accornero P, Martignani E, Miretti S, et al. Epidermal growth factor and hepatocyte growth factor receptors collaborate to induce multiple biological responses in bovine mammary epithelial cells[J]. J Dairy Sci, 2009, 92(8):3667~3675.
9 Akers R M. Major advances associated with hormone and growth factor regulation of mammary growth and lactation in dairy cows[J]. J Dairy Sci,2006,89(4): 1222~1234.
10 Ali S, Ali S. Prolactin receptor regulates Stat5 tyrosine phosphorylation and nuclear translocation by two separate pathways[J]. J Biol Chem, 1998, 273: 7709~7716.
11 Brodbeck V,Denton W L,Tanahashi N, et al. The isolation and identification of the B protein of lactose synthetase as α-lactalbumin[J]. J Biol Chem,1967,242:1391~1397.
12 Burnol A F,Ferre P,Leturque A,et al. Effect of insulin on in vivo glucose utilization in individual tissues of anaesthetized lactating rats[J]. J Am Physiol Endocrinol Metab,1987,252: E183~E188.
13 Burnol A F,Letirque A,Loizeau M,et al. Glucose transporter expression in rat mammary gland[J]. J Biochem, 1990, 270: 277~279.
14 Camps M,Vilaro S,Testar X,et al. High and polarized expression of GLUT1 glucose transporters in epithelial cells from mammary gland: Acute downregulation of GLUT1 carriers by weaning[J]. J Endocrinology,1994,134: 924~934.
15 Cant J P,Trout D R,Qiao F,et al. Milk synthetic response of the bovine mammary gland to an increase in the local concentration of arterial glucose[J]. J Dairy Sci, 2002,85:494~503.
16 Cosman D, Lyman S D, Idzerda R L, et al. A new cytokine receptor superfamily[J]. Trends Biochem Sci,1990,15:265~270.
17 Forsyth I A. Variation among species in the endocrine control of mammary growth and function: The roles of prolactin, growth hormone and placental lactogen[J]. J Dairy Sci, 1986,69(3):886~903.
18 Gallego M I, Binart N, Robinson G W, et al. Prolactin, growth hormone and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects[J]. Dev Biol, 2001, 229(1):163~175.
19 Haney P M. Localization of the GLUT1 glucose transporter to brefeldin A-sensitive vesicles of differentiated CIT3 mouse mammary epithelial cells[J]. Cell Biol Int,2001,25:277~288.
20 Huhtanen P,Vanhatalo A,Varvikko T. Effects of abomasal infusions of histidine, glucose, and leucine on milk production and plasma metabolites of dairy cows fed grass silage diets[J]. J Dairy Sci,2002,85:204~216.
21 Jenkins T C,McGuire M A. Major advances in nutrition: Impact on milk composition[J].J Dairy Sci,2006,89:1302~1310.
22 Kronfeld D S. Major metabolic determinants of milk volume, mammary efficiency, and spontaneous ketosis in dairy cows[J]. J Dairy Sci, 1982, 65(11):2204~2212.
23 Lacasse P,Lollivier V,Dessauge F,et al. New developments on the galactopoietic role of prolactin in dairy ruminants[J]. Domest Anim Endocrinol, 2012,43(2):154~160.
24 Le Roith D,Bondy C,Yakar S,et al. The somatomedin hypothesis: 2001[J]. Endocr Rev, 2001,22(1):53~74.
25 Leonard W J, O’Shea J J. JAKS and STATS: Biological implications[J]. Annu Rev Immunol,1998, 16:293~322.
26 Macheda M L, Williams E D, Best J D, et al. Expression and localisation of GLUT1 and GLUT12 glucose transporters in the pregnant and lactating rat mammary gland[J]. Cell Tissue Res, 2003, 311:91~97.
27 Madon R J, Martin S, Davies A, et al. Identification and characterization of glucose transport proteins in plasma membrane-and Golgi vesicle-en-riched fractions prepared from lactating rat mammary gland[J]. J Biochem, 1990, 272:99~105.
28 Massimo B, Loor J J. Gene networks drving bovine mammary protein synthesis during the lactation cycle[J]. J Bioinformatics and Biology Insights, 2011, 5: 83~98.
29 Pessin J E, Saltiel A R. Signaling pathways in insulin action: Molecular targets of insulin resistance[J]. J Clin Invest, 2000,106(2):165~169.
30 Sachdev D,Yee D. Inhibitors of insulin-like growth factor signaling: A therapeutic approach for breast cancer[J]. J Mammary Gland Biol Neoplasia,2006, 11(1):27~39.
31 Schaefer F,Yoon S A,Nouri P,et al. Growth hormone-mediated janus associated kinase-signal transducers and activators of transcription signaling in the growth hormone-resistant potassium-deficient rat[J]. Am Soc Nephrol, 2004, 15(9): 2299~2306.

32Scott R A, Bauman D E,Clark J H. Cellular gluconeogenesis by lactating bovine mammary tissue[J]. J Dairy Sci,1976,59:50~56.
33 Shahbazkia H R, Aminlari M, Cravador A. Association of polymorphism of the β(1, 4)-galactosyltransferase-Ⅰ gene with milk production traits in Holsteins[J]. Mol Biol Rep, 2012,39(6):6715~6721.
34 Shennan D B, Peaker M. Transport of milk constituents by the mammary gland[J]. Physiol Rev, 2000, 80:925~951.
35 Su H, Jiang L, Carter-Su C, et al. Glucose enhances leptin signaling through modulation of AMPK activity[J]. PLoS One, 2012,7(2):e31636.
36 Sunehag A L,Louie K,Bier J L, et al. Hexoneogenesis in the human breast during lactation[J]. J Clin Endocrinol and Metab, 2002,87(1):297~301.
37 Swaminathan G, Varghese B, Fuchs S Y. Regulation of prolactin receptor levels and activity in breast cancer[J]. J Mammary Gland Biol Neoplasia, 2008, 13(1): 81~91.
38 Takeda K, Akira S. STAT family of transcription factors in cytokine-mediated biological responses[J]. Cytokine Growth FactorRev, 2000, 11:199~207.
39 Tamburini J,Chapuis N,Bardet V,et al. Mammalian target of rapamycin(mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-Ⅰ receptor signaling in acute myeloid leukemia: Rationale for therapeutic inhibition of both pathways[J]. Blood, 2008, 111: 379~382.
40 Tan S X, Ng Y, James D E. Akt inhibitors reduce glucose uptake independently of their effects on Akt[J]. J Biochem, 2010,432(1):191~197.
41 Thorn S R, Purup S, Cohick W S, et al. Leptin does not act directly on mammary epithelial cells in prepubertal dairy heifers[J]. J Dairy Sci, 2006, 89(5):1467~1477.
42 Trenkle A. Endocrine regulation of energy metabolism in ruminants[J]. Fed Proc,1981,40:2536~2541.
43 Vilotte J L. Lowering the milk lactose content in vivo: Potential interests, strategies and physiological consequences[J]. Reprod Nutr ,2002, 42:127~132.
44 Wagner K U, Krempler A, Triplett A A, et al. Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice[J]. Mol Cell Biol,2004, 24: 5510~5520.
45 Wickramasinghe S, Rincon G, Islas-Trejo A, et al. Transcriptional profiling of bovine milk using RNA sequencing[J]. BMC Genomics, 2012,13(1):45.
46 Yang J, Kennelly J J, Baracos V E. The activity of transcription factor State5 responds to prolactin, growth hormone, and IGF-Ⅰ in rat and bovine mammary explant culture[J]. J Animal Science, 2000,78: 3114~3125.
47 Zhao F Q, Glimm D R,Kennelly J J. Distribution of mammalian facilitative glucose transporter messenger RNA in bovine tissues[J]. J Int Biochem, 1993,25: 1897~1903.
48 Zhao F Q, Okine E K, Suominen A H, et al. Expression of Na1/glucose cotransporter gene in the gastrointestinal tract and the mammary gland of lactating cows[J]. J Dairy Sci, 1996a,79:145.
49 Zhao F Q, Moseley M W, Tucker H A, et al. Regulation of glucose transporter gene expression in mammary gland,muscle and fat of lactating cows by administration of bovine growth hormone and bovine growth hormone-releasing factor[J]. J Anim Sci,1996b, 74:183~189.
50 Zhao F Q, Keating A F. Functinal properties and genomics of glucose transporters[J]. J Current Genomics, 2007a,8: 113~128.
51 Zhao F Q, Keating A F. Expression and regulation of glucose transporters in the bovine mammary gland[J].J Dairy Sci, 2007b,90:E76~E86.

[1]	BAO Yuexian, ZHAO Feifei, GONG Wendian, LU Zeyu, MU Qing, LIU Junyang, TE Rigele, ZHAO Yanhong. Effects of Prolactin on Hair Follicle Culture of Inner Mongolia Cashmere Goats in vitro [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2072-2078.
[2]	WEI Yunfang, LI Feixiang, Xing Yun, Huang Qingguo, LI Judong, WAN Jiusheng, CHEN Fangliang. Study on Cloning, Bioinformatics Analysis and Spatio-temporal Expression of IGF2 Gene in Kunming Dogs [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 866-875.
[3]	SUN Qingshuai, YAN Weidong, LI Chang, WU Hao, LI Changchun, HE Qigai. Effect of PCV3 on the Expression of Growth-related Hormones and Functional Genes in Piglets [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 1041-1047.
[4]	ZHANG Runxiang, BAI Yuting, ZHANG Yinglei, LIU Keke, WANG Xinyu, DONG Yinyu, WANG Xiaoli. Effect of Gynostemma pentaphyllum Polysaccharide on Antioxidative Ability of Liver in Aging Mice Induced by D-galactose [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(2): 462-470.
[5]	CAO Yue, LI Dabiao. Regulatory Effects of Hormones on Milk Fat Synthesis in Bovine Mammary Epithelial Cells [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(8): 2778-2786.
[6]	YU Houmo, ZHU Lei, ZHANG Hailiang, CHANG Yao, YANG Tongtong, GUO Gang, LIU Lin, WANG Yachun. Analysis of Influencing Factors and Estimation of Genetic Parameters for Lactose Percentage in Holstein Cows in Beijing [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(12): 4520-4529.
[7]	LI Yan, XU Hongyue, LI Shulin, WANG Xueyan, TANG Xudong, YU Lu. Study on Cordycepin Prevents Obesity and Mediates Prolactin Secretion Through ADORA₁ in GH3 Cells [J]. , 2018, 45(5): 1382-1388.
[8]	SU Jun, LIU Man, WANG Jigui, SUN Yan, LIU Weiquan. Prokaryotic Expression and Specific Antiserum Preparation of Mink Growth Hormone [J]. , 2018, 45(4): 866-872.
[9]	LUO Cheng-long, ZHAO Yan-kun, WU Kai-le, SHAO Wei. Study on Effect of IGF-1 on Proliferation and Apoptosis of Bovine Mammary Epithelial Cells by Adding Inhibitor [J]. , 2017, 44(8): 2277-2282.
[10]	LU Yan-juan, WANG Xiao-fang, ZENG Jie, CHEN Yu-lin, ZHANG En-ping. Effects of Diets with Different Energy and Protein Levels on mRNA Expression of Glucose Transporters in Tan Sheep [J]. , 2017, 44(6): 1657-1665.
[11]	LIU Tian, GONG Qiang, LI Xiang-zi, GAO Qing-shan, YAN Chang-guo. Effects of Castration at 6 Months Old on Growth Performance, Testosterone and Growth Hormone Levels in Blood of Yanbian Cattle [J]. , 2017, 44(10): 2937-2943.
[12]	WANG Peng, GUAN Qing-feng, HUA Rui, CAI Ke-qi, YANG Hui, HOU Guan-yu, WU Ke-bang. Study on Regulation of Reproductive Hormones in Danzhou Chicken by FSH and LH [J]. , 2017, 44(10): 3029-3034.
[13]	YU Jian-feng, HE Sai, JIN Ze-kai, ZHOU Huan-qing, DONG Xiao-min, GONG Dao-qing, GU Zhi-liang. Expression,Purification and Biological Activity Identification of Chicken Growth Hormone in Pichia pastoris [J]. , 2016, 43(11): 2970-2975.
[14]	XIE Xue-jiao, LUAN Sheng, WANG Yuan, ZHANG Li, CUI Ying-jun, WANG Chun-mei, LI Qing-zhang. Effect of miR-142-3p on Cell Proliferation of Human Mammary Epithelial Cells MCF-10A and Synthesis of Milk Protein [J]. , 2015, 42(7): 1680-1685.
[15]	TAO Xuan, GU Yi-ren, LIANG Yan, YANG Xue-mei, ZENG Kai, CHEN Xiao-hui, YANG Yue-kui, ZHONG Zhi-jun, LV Xue-bin. Study on Developmental Changes of Growth Hormone (GH) and Growth Hormone Releasing Hormone (GHRH) in Serum of Pigs [J]. , 2015, 42(12): 3288-3293.

Research Progress on Genes and Signal Pathways Associated with Lactose Synthesis and Lactation in Dairy Cows

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments