肺动脉内皮细胞在肉鸡腹水综合征中的作用及miRNA调控机制的研究进展

doi:10.16431/j.cnki.1671-7236.2025.04.007

Abstract

Abstract: Broiler ascites syndrome is a nutritional metabolic disease caused by multiple etiology,which is related to heredity,feeding management,nutritional imbalance and environment.Since its first appearance,the disease has caused serious economic losses to the global poultry industry.Research indicates that systemic hypoxia is an important cause of ascites in broilers.Prolonged hypoxia can lead to the injury of pulmonary artery endothelial cells (PAECs),resulting in functional disorders,excessive production of vasoactive factors,abnormal contraction of vascular smooth muscles,and exacerbation of abnormal proliferation,inflammatory responses,and phenotypic transformation of vascular endothelium. Over time,these changes will lead to complex pathological processes such as the thickening of the vascular media and the gradual narrowing of the lumen,which will promote pulmonary artery remodeling and eventually become the direct inducement of ascites formation.As epigenetic regulatory factors,miRNA plays an important role in regulating various signal transduction pathways and thus affecting cell physiological functions.In the formation of pulmonary hypertension,miRNA plays a particularly significant role in regulating the physiological process of pulmonary artery endothelial cells.Consequently,the author discussed the etiology and pathogenesis of broiler ascites syndrome,clarified the functional changes of pulmonary artery endothelial cells and the key role of miRNA in this complex disease process,in order to provide reference for the prevention and control of broiler ascites syndrome.

Key words: broiler ascites syndrome; pulmonary artery endothelial cells (PAECs); pulmonary hypertension; miRNA

CLC Number:

S856.5

JIANG Chenxi, CHENG Sufang, WU Guozao, CHEN Juan, GAO Xiaona, GUO Xiaoquan, LIU Ping. Research Progress on the Role of Pulmonary Artery Endothelial Cells in Broiler Ascites Syndrome and the Regulation Mechanism of miRNA[J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(4): 1522-1532.

References

[1] 孙卫东,王金勇,谭勋,等.肉鸡腹水综合征及其研究进展[J].中国兽医学报,2008,5:608-617.SUN W D,WANG J Y,TAN X,et al.Ascites syndrome in broilers and its research progress[J].Chinese Journal of Veterinary Medicine,2008,5:608-617.(in Chinese)
[2] 苏晓菲.肉鸡腹水综合征实验模型构建与芪苓归腹方对其血管内皮功能作用研究[D].太古:山西农业大学,2015.SU X F.Multifactorial methods construct ascites syndrome of broiles and protective effect of vascular endothelial function from Qilinggui Fufang for the disease[D].Taigu:Shanxi Agricultural University,2015.(in Chinese)
[3] 赵诗洁.红景天苷对鸡胚肺血管内皮细胞、肺血管平滑肌细胞及心肌细胞中HIF-1α表达的影响[D].武汉:华中农业大学,2014.ZHAO S J.Effects of the expression of hypoxia-inducible factor-1A in pulmonary vascular endothelial cells,pulmonary artery smooth muscle cells and cardiomyocytes of chicken embryo in hypoxia[D].Wuhan:Huazhong Agricultural University,2014.(in Chinese)
[4] 陈宴冲.肉鸡腹水症发生原因及治疗措施[J].中国畜牧业,2023,4:113-114.CHEN Y C.Causes and treatment of ascites in broilers[J].China Animal Husbandry,2023,4:113-114.(in Chinese)
[5] 崔亮,王珂瑶,张新平,等.复方中药对腹水综合征肉鸡肺组织炎症-增殖的调控研究[J].中国畜牧兽医,2023,50(8):3373-3383.CUI L,WANG K Y,ZHANG X P,et al.Study on the regulation of compound traditional Chinese medicine on inflammation-proliferation of lung tissue in broilers with ascites syndrome[J].China Animal Husbandry&Veterinary Medicine,2023,50(8):3373-3383.(in Chinese)
[6] EVANS C E,COBER N D,DAI Z,et al.Endothelial cells in the pathogenesis of pulmonary arterial hypertension[J].The European Respiratory Journal,2021,58(3):2003957.
[7] 滕慧芳,秦仕虹,符代炎.肺动脉内皮细胞炎症反应在低氧性肺动脉高压中的作用研究进展[J].实用心脑肺血管病杂志,2023,31(7):33-39.TENG H F,QIN S H,FU D Y.Research progress on the role of inflammatory response pulmonary artery endothelial cell in hypoxic pulmonary hypertension[J].Journal of Practical Cardiovascular and Pulmonary Vascular Diseases,2023,31(7):33-39.(in Chinese)
[8] 陈昌贵,易春峰,余志华,等.GW501516对低氧致肺动脉内皮细胞损伤的影响及机制[J].中国药房,2024,35(2):179-185.CHEN C G,YI C F,YU Z H,et al.Effects of GW501516 on the injury of pulmonary artery endothelial cells induced by hypoxia and its mechanismJ].China Pharmacy,2024,35(2):179-185.(in Chinese)
[9] 李娜,李占强,芦殿香.靶向肺血管内皮功能障碍治疗肺动脉高压的研究进展[J].中国药理学通报,2024,40(1):1-5.LI N,LI Z Q,LU D X.Research progress of targeted pulmonary vascular endothelial dysfunction in treatment of pulmonary hypertension[J].Chinese Pharmacologic Bulletin,2024,40(1):1-5.(in Chinese)
[10] 陈琴.miR-26b-3p/CD73调控肺动脉内皮细胞焦亡在肺动脉高压中的作用[D].长沙:中南大学,2022.CHEN Q.miR-26b-3p/CD73 axis regulates pyroptosis of pulmonary artery endothelial cell in pulmonary hypertension[D].Changsha:Central South University,2022.(in Chinese)
[11] 崔艳红,刘培培,孙潺.miR-21-5p抑制缺氧诱导的肺动脉内皮细胞损伤[J].中国组织化学与细胞化学杂志,2021,30(6):558-563.CUI Y H,LIU P P,SUN C.miR-21-5p inhibits hypoxia-induced pulmonary artery endothelial cell injury[J].Chinese Journal of Histochemistry and Cytochemistry,2021,30(6):558-563.(in Chinese)
[12] 杨蛟,杨礼.肉鸡腹水综合征的病因与防控措施[J].畜牧兽医科技信息,2023,11:59-60.YANG J,YANG L.Causes and preventive and control measures of ascites syndrome in broilers[J].Chinese Journal of Animal Husbandry and Veterinary Medicine,2023,11:59-60.(in Chinese)
[13] 戴爱琴.肉鸡腹水综合征的发病原因与综合防治[J].吉林畜牧兽医,2021,42(10):50-52.DAI A Q.Pathogenesis and comprehensive control of ascites syndrome in broilers[J].Jilin Animal Husbandry and Veterinary Medicine,2021,42(10):50-52.(in Chinese)
[14] 郭宇荣,崔亮,苏晓菲,等.多因素法构建肉鸡腹水综合征实验模型及其对肺组织血管内皮舒缩活性因子的影响[J].中国畜牧兽医,2020,47(5):1350-1359.GUO Y R,CUI L,SU X F,et al.Establishment of ascites syndrome model in broiler induced by multi-factor and its effect on diastolic-systolic activity factors of vascular endothelium in lung tissue[J]. China Animal Husbandry&Veterinary Medicine,2020,47(5):1350-1359.(in Chinese)
[15] 徐志敏.肉鸡腹水综合征及中兽药的应用[J].家禽科学,2024,46(8):77-79.XU Z M.Ascites syndrome in broilers and the application of Chinese veterinary medicine[J]. China Poultry Science,2024,46(8):77-79.(in Chinese)
[16] 李子秀.肉鸡腹水综合征的发病原因及综合防治[J].吉林畜牧兽医,2022,43(3):50-51.LI Z X.Pathogenesis and comprehensive control of ascites syndrome in broiler chickens[J].Jilin Animal Husbandry&Veterinary Medicine,2022,43(3):50-51.(in Chinese)
[17] KHAJALI F.Managing broiler production challenges at high altitude[J].Veterinary Medicine and Science,2022,8(4):1519-1527.
[18] 张学勇,简莹娜,郭志宏.浅析肉鸡腹水综合征的发生与防治[J].青海畜牧兽医杂志,2020,50(1):61-65.ZHANG X Y,JIAN Y N,GUO Z H.Analysis of the occurrence and prevention of ascites syndrome in broilers[J].Chinese Qinghai Journal of Animal Husbandry and Veterinary Sciences,2020,50(1):61-65.(in Chinese)
[19] 苗新竹,闫家稷,张杰.肉鸡腹水综合征的病因及防治[J].吉林畜牧兽医,2021,42(7):38-41.MIAO X Z,YAN J J,ZHANG J.Causes and prevention of ascites syndrome in broilers[J].Jilin Animal Husbandry and Veterinary Medicine,2021,42(7):38-41.(in Chinese)
[20] 臧金运.肉鸡腹水综合征的临床特征和预防措施[J].吉林畜牧兽医,2022,43(12):61-62.ZANG J Y.Clinical characteristics and preventive measures of ascites syndrome in broilers[J]. Jilin Animal Husbandry and Veterinary Medicine,2022,43(12):61-62.(in Chinese)
[21] 张娟.复方中药对肉鸡腹水综合征肺组织内皮活性因子的作用机制研究[D].太谷:山西农业大学,2017.ZHANG J.Effect of compound traditional Chinese medicine on endothelial activity factors of lung tissue in broiler with ascites syndrome[D].Taigu:Shanxi Agricultural University,2017.(in Chinese)
[22] JULIAN R J.Ascites in poultry[J].Avian Pathology,1993,22(3):419-454.
[23] 顾玥明.肉鸡肺动脉JAZF1和RPS14蛋白多克隆抗体的制备及其在肉鸡腹水综合征中的表达量分析[D].南昌:江西农业大学,2023.GU Y M.Preparation of polyclonal antibodies against JAZF1 and RPS14 proteins in broiler pulmonary arteries and their expression analysis in broiler ascites syndrome[D].Nanchang:Jiangxi Agricultural University,2023.(in Chinese)
[24] 郭凤萍.RNA干扰HIF-1α基因对肉鸡肺动脉内皮细胞的作用研究[D].南昌:江西农业大学,2022.GUO F P.Study on the effect of RNA interference with HIF-1α gene on pulmonary artery endothelial cells in broiler chickens[D].Nanchang:Jiangxi Agricultural University,2022.(in Chinese)
[25] 李嘉威.缺氧条件下MIF对肉鸡肺动脉平滑肌细胞增殖的影响[D].太谷:山西农业大学,2021.LI J W.The effects of migration inhibitory factor on proliferation of broiler chicken pulmonary artery smooth muscle cells in hypoxia[D].Taigu:Shanxi Agricultural University,2021.(in Chinese)
[26] 李悦梅.高血压血管重构的研究进展[J].中国动脉硬化杂志,2003,2:171-174.LI Y M.Progress of vascular remodelling in hypertension[J].Chinese Journal of Atherosclerosis,2003,2:171-174.(in Chinese)
[27] WIDEMAN R F,RHOADS D B,ERF G F,et al.Pulmonary arterial hypertension (ascites syndrome) in broilers:A review[J]. Poultry Science,2013,92(1):64-83.
[28] 谭勋.肉鸡肺动脉高压综合征发病机理及防治的研究[D].南京:南京农业大学,2004.TAN X.Pathogenesis and control of pulmonary hypertension in broilers[D].Nanjing:Nanjing Agricultural University,2004.(in Chinese)
[29] 王婷慧.复方中药对肉鸡腹水综合征的防治作用及基于Akt/mTOR通路的机制研究[D].太谷:山西农业大学,2022.WANG T H.Effect of Chinese herbal compounds on ascites syndrome in broilers and its mechanism based on Akt/mTOR pathway[D].Taigu:Shanxi Agricultural University,2022.(in Chinese)
[30] 李凯.肉鸡腹水综合征不同器官组织的显微结构观察及HIF-1α、VEGF差异性表达分析[D].阿拉尔:塔里木大学,2022.LI K.Microstructural observation of different organs tissues of broiler ascites syndrome and analysis of differential expression on HIF-1α and VEGF[D].Alaer:Tarim University,2022.(in Chinese)
[31] ANTHONY N B,BALOG J M,STAUDINGER F B,et al.Effect of a urease inhibitor and ceiling fans on ascites in broilers[J]. Poultry Science,1994,73(6):801-809.
[32] 王慧敏.基于Rho/ROCK通路研究复方中药对腹水综合征肉鸡组织纤维化的防治机制[D].太谷:山西农业大学,2023.WANG H M.Study on the preventive and therapeutic mechanism of compound Chinese medicine on tissue fibrosis in broilers with ascites syndrome by based on Rho/ROCK pathway[D]. Taigu:Shanxi Agricultural University,2023.(in Chinese)
[33] 温爽,郭宇荣,杨澜,等.腹水综合征肉鸡空肠黏膜组织结构及相关基因表达分析[J].中国畜牧兽医,2019,46(6):1825-1831.WEN S,GUO Y R,YANG L,et al.Analysis of histological structure and expression of related genes in jejunum mucosa of broilers ascites syndrome[J].China Animal Husbandry&Veterinary Medicine,2019,46(6):1825-1831.(in Chinese)
[34] CURRIE R J W.Ascites in poultry:Recent investigations[J]. Avian Pathology,1999,28(4):313-326.
[35] 郑轲.脲酶抑制剂和脲酶卵黄抗体对肉鸡腹水症影响的研究[D].成都:四川农业大学,2006.ZHENG K.Effects of urease inhibitors and anti-urease immunoglobulin Y on ascites in broilers[D].Chengdu:Sichuan Agricultural University,2006.(in Chinese)
[36] 张万顺,李文学,付志刚.用脲酶抑制剂和除臭灵控制肉仔鸡腹水症的比较试验[J].养禽与禽病防治,1997,9:7-8.ZHANG W S,LI W X,FU Z G.Comparative test of urease inhibitor and deodorant for the control of ascites in broilers[J].Poultry Husbandry and Disease Control, 1997,9:7-8.(in Chinese)
[37] 温爽.复方中药对腹水综合征肉鸡空肠紧密连接和炎症因子的影响[D].太谷:山西农业大学,2019.WEN S.Effects of compound traditional Chinese medicines on jejunum tight junction and inflammatory factors in broilers with ascites syndrome[D].Taigu:Shanxi Agricultural University,2019.(in Chinese)
[38] FORMAN M F,WIDEMAN R F.Measurements of pulmonary arterial pressure in anesthetized male broilers at two to seven weeks of age[J].Poultry Science,2000,79(11):1645-1649.
[39] 罗伏兵.心钠素在肉鸡腹水综合症发病过程中的变化研究[D].北京:中国农业大学,2004.LUO F B.Study of atrial natriuretic peptidein of ascites syndrome in broilers[D]. Beijing:China Agricultural University,2004.(in Chinese)
[40] 单晓茜,郑秋玉,陈璐,等.肺血管内皮细胞功能障碍在肺动脉高压中的研究进展[J].内蒙古医科大学学报,2023,45(2):204-208.SHAN X X,ZHENG Q Y,CHEN L,et al.Progress of pulmonary vascular endothelial cell dysfunction in pulmonary arterial hypertension[J].Journal of Inner Mongolia Medical University,2023,45(2):204-208.(in Chinese)
[41] 贺雅婷,刘海杰,马晓峰.内皮细胞在血液循环及炎症反应中的作用[J].中国城乡企业卫生,2019,34(4):28-31.HE Y T,LIU H J,MA X M.Role of endothelial cells in blood circulation and inflammatory response[J].Chinese Journal of Urban and Rural Enterprise Hygiene,2019,34(4):28-31.(in Chinese)
[42] CYR A R,HUCKABY L V,SHIVA S,et al.Nitric oxide and endothelial dysfunction[J].Critical Care Clinics,2020,36(2):307-321.
[43] 杨志虹,杨孝芳,张宁,等.体外适宜温热刺激对络脉相关血管内皮细胞血管舒缩物质ET-1、TM、PGI₂的影响[J].中华中医药杂志,2018,33(1):284-286.YANG Z H,YANG X F,ZHANG N,et al.Effects of external thermal stimulation on the vasomotor regulation substances ET-1,TM,and PGI₂ of collaterals related vascular in endothelial cells[J].Chinea Journal of Traditional Chinese Medicine and Pharmacy,2018,33(1):284-286.(in Chinese)
[44] 孙扬.内皮素-1对体外培养的肉鸡肺动脉内皮细胞的影响[D].武汉:华中农业大学,2007.SUN Y.The effect of endothelin-1 on pulmonary artery endothelial cells of broilers[D].Wuhan:Huazhong Agricultural University,2007.(in Chinese)
[45] JULIAN R J,MCMILLAN I,QUINTON M.The effect of cold and dietary energy on right ventricular hypertrophy,right ventricular failure and ascites in meat-type chickens[J]. Avian Pathology,1989,18(4):675-684.
[46] 欧德渊,高铭宇,陈红,等.血管内皮生长因子在肉鸡腹水综合征形成中的作用[J].中国兽医科技,2005,5:404-408.OU D Y,GAO M Y,CHEN H,et al.Role of vascular endothelial growth factor development of ascites syndrome in broilers[J]. Chinese Veterinary Science and Technology,2005,5:404-408.(in Chinese)
[47] ZHANG W,LI Y,XIN X,et al.microRNA-15a-5p induces pulmonary artery smooth muscle cell apoptosis in a pulmonary arterial hypertension model via the VEGF/p38/MMP-2 signaling pathway[J].International Journal of Molecular Medicine,2020,45(2):461-474.
[48] REITERER M,BRANCO C.Endothelial cells and organ function:Applications and implications of understanding unique and reciprocal remodelling[J].The FEBS Journal, 2019,287(6):1088-1100.
[49] JIN Q,SHAN H,YANG R,et al.C1q/TNF-related protein-9 ameliorates hypoxia-induced pulmonary hypertension by regulating secretion of endothelin-1 and nitric oxide mediated by AMPK in rats[J].Scientific Reports,2021,11(1):11372.
[50] 赵倩,曹静,李明霞.热休克蛋白70调控Bcl-2/Bax对缺氧性肺高压新生大鼠肺血管内皮细胞凋亡及肺动脉压力的作用[J].新疆医科大学学报,2021,44(9):981-988.ZHAO Q,CAO J,LI M X.Role of heat shock protein 70 regulating Bcl-2/Bax on apoptosis of pulmonary vascular endothelial cells and pulmonary arterial pressure of hypoxic pulmonary hypertension in neonatal rats[J].Journal of Xinjiang Medical University,2021,44(9):981-988.(in Chinese)
[51] 郭迪森.IL-6通过JAK2/STAT3调控人肺动脉内皮细胞的代谢和功能[D].沈阳:中国医科大学,2024.GUO D S.IL-6 regulates the metabolism and function of human pulmonary artery endothelial cells via JAK2/STAT3[D]. Shenyang:China Medical University,2024.(in Chinese)
[52] 蔡雪黎.积雪草苷对血管内皮细胞的保护作用及机制研究[D].苏州:苏州大学,2019.CAI X L.Protective effect and asiaticoside on vascular endothelial cell and its potential mechanism[D].Suzhou:Soochow University,2019.(in Chinese)
[53] 王洪麦,夏晴晴,盖祥云,等.低氧诱导内皮-间充质转化致肺血管重构及药物干预研究进展[J].中国药理学与毒理学杂志,2024,38(3):232-240.WANG H M,XIA Q Q,GAI X Y,et al.Research progress in hypoxia-induced endothelial-to-mesenchymal transition induced pulmonary vascular remodeling and drug interventions[J].Chinese Journal of Pharmacology and Toxicology,2024,38(3):232-240.(in Chinese)
[54] 刘蕾,马德宾,史亮,等.Shh/Twist1对大鼠肺动脉内皮细胞间质转化及血管重构的作用机制[J].贵州医科大学学报,2022,47(1):45-50.LIU L,MA D B,SHI L,et al.Study on the mechanism of Shh/Twist1 on pulmonary artery endothelial cell mesenchymal transformation and vascular remodeling[J].Journal of Guizhou Medical University,2022,47(1):45-50.(in Chinses)
[55] 黎璟睿,谢江,范正阳,等.PPARγ对持续缺氧阵发加剧形式培养的肺动脉内皮细胞保护机制的研究[J].心肺血管病杂志,2022,41(1):92-97.LI J R,XIE J,FAN Z Y,et al.Protective mechanism of PPARγ on HPAECs exposed to persistent hypoxia along with intermittent aggravation[J].Journal of Cardiopulmonary Vascular Disease,2022,41(1):92-97.(in Chinses)
[56] BUSHATI N,COHEN S M.microRNA functions[J].Annual Review of Cell and Developmental Biology,2007,23:175-205.
[57] VIZCAÍNO F P,MONDÉJAR-PARREÑO G.Antiproliferative miR-212-5p:Promising RNA therapy for pulmonary hypertension[J].Molecular Therapy-Nucleic Acids,2022,29:689-690.
[58] LIU T,ZOU X,HUANG N,et al.Down-regulation of miR-204 attenuates endothelial-mesenchymal transition by enhancing autophagy in hypoxia-induced pulmonary hypertension[J].European Journal of Pharmacology,2019,863:172673.
[59] COURBOULIN A,PAULIN R,GIGUōRE N J,et al.Role for miR-204 in human pulmonary arterial hypertension[J].Journal of Experimental Medicine,2011,208:535-548.
[60] YUE Y,ZHANG Z,ZHANG L,et al.miR-143 and miR-145 promote hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells through regulating ABCA1 expression[J].Cardiovascular Pathology,2018,37:15-25.
[61] BOCKMEYER C L,MAEGEL L,RISCHE J,et al.Expression of miR143/145 and smooth muscle differentiation markers in vascular compartments of pulmonary hypertension[J].American Journal of Respiratory and Critical Care Medicine,2011,183:A3447.
[62] 王英杰.miR-29靶向调控LRP6介导Wnt/β-catenin抑制肺动脉高压EndMT的机制研究[D].沈阳:中国医科大学,2022.WANG Y J.The mechanism of miR-29 targeting LRP6-mediated Wnt/β-catenin inhibition of EndMT in pulmonar hypertension of the newborn[D].Shenyang:China Medical University,2022.(in Chinese)
[63] ZHANG H,WANG D,LI M,et al.Metabolic and proliferative state of vascular adventitial fibroblasts in pulmonary hypertension is regulated through a microRNA-124/PTBP1(polypyrimidine tract binding protein 1)/pyruvate kinase muscle axis[J].Circulation,2017,136(25):2468-2485.
[64] 朱键,陈天天,刘智勇,等.microRNA-124过表达对肺动脉高压大鼠肺血管重构的影响[J].新医学,2023,54(8):554-559.ZHU J,CHEN T T,LIU Z Y,et al.Effect of overexpression of microRNA-124 on pulmonary vascular remodeling in rats with pulmonary arterial hypertension[J].New Medicine,2023,54(8):554-559.(in Chinese)
[65] 张岩伟.miR-140在先天性心脏病肺动脉高压的作用机制[D].郑州:郑州大学,2016.ZHANG Y W.The effect mechanism of miR-140 in pulmonary artetial hypertension complicated with congenital heart disease[D].Zhengzhou:Zhengzhou University,2016.(in Chinese)
[66] 吴卫华.microRNA-130a在血管平滑肌细胞增殖及血管重构中的作用[D].长沙:中南大学,2013.WEI W H.Role of microRNA-130a in proliferation of vascular smooth muscle cell and vascular remodeling[D].Changsha:Central South University,2013.(in Chinese)
[67] CARUSO P,MACLEAN M R,KHANIN R,et al.Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2010,30(4):716-723.
[68] CHEN T,ZHOU G,ZHOU Q,et al.Loss of microRNA-17~92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5[J].American Journal of Respiratory and Critical Care Medicine,2015,191(6):678-692.
[69] CHEN T,SUN M,ZHOU Q,et al.microRNA-212-5p,an anti-proliferative miRNA,attenuates hypoxia and sugen/hypoxia-induced pulmonary hypertension in rodents[J].Molecular Therapy-Nucleic Acids,2022,29:204-216.
[70] MA W,QIU Z,BAI Z,et al.Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension[J].Molecular Therapy-Nucleic Acids,2021,26:678-693.
[71] LIU P,YANG F,ZHANG Y,et al.Dysregulated expression of microRNAs and mRNAs in pulmonary artery remodeling in ascites syndrome in broiler chickens[J].Oncotarget,2016,8(2):1993-2007.
[72] SANTOS-FERREIRA C A,ABREU M T,MARQUES C I,et al.micro-RNA analysis in pulmonary arterial hypertension:Current knowledge and challenges[J].JACC:Basic to Translational Science,2020,5(11):1149-1162.
[73] 申翔,梁隆斌,徐尚刚,等.miR-29a对Dicer基因敲除小鼠心脏重构的调节作用[J].中国急救医学,2021,41(9):797-802.SHEN X,LIANG L B,XU S G,et al.Regulation of miR-29a on cardiac remodeling in Dicer knockout mice[J].China Emergency Medicine,2021,41(9):797-802.(in Chinese)
[74] 陆洲成,桂培根.miRNAs与血管损伤及血管重塑[J].心血管病防治知识(学术版),2019,2:93-96.LU Z C,GUI P G.miRNAs and vascular injury and vascular remodeling[J].Cardiovascular Disease Prevention and Control Knowledge (Academic Edition),2019,2:93-96.(in Chinese)
[75] ANAND S,CHERESH D A.Emerging role of micro-RNAs in the regulation of angiogenesis[J].Genes&Cancer,2011,2(12):1134-1138.
[76] ANAND S,MAJETI B K,ACEVEDO L M,et al.microRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis[J]. Nature Medicine,2010,16(8):909-914.
[77] 罗怡萱.缺氧诱导下人肺动脉内皮细胞的miRNA组学分析及功能研究[D].深圳:深圳大学,2019.LUO Y X.miRNA omics analysis and functional study of human pulmonary artery endothelial cells induced by hypoxia[D].Shenzhen:Shenzhen University,2019.(in Chinese)

Research Progress on the Role of Pulmonary Artery Endothelial Cells in Broiler Ascites Syndrome and the Regulation Mechanism of miRNA

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LI Zhiyi, LI Jie, CHEN Chuwen, NONG Yi, WANG Jiayan, WANG Zi, WU Jinbo, LI Zhixiong. Analysis and Identification of miRNA in Leg Muscle Tissue of Tibetan Chicken Embryos at Different Developmental Stages [J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(4): 1681-1693.
[2]	LI Jingxuan, LIN Yanjiao, HUANG Qiongjun, HAN Xinyan, ZHANG Yuelang. Research Progress on Non-coding RNA Related to Skeletal Muscle Development in Goats [J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(2): 582-592.
[3]	WANG Yong, MA Chi, WANG Chao, ZHAO Qinan, SUN Zhipeng, TIAN Feng, WANG Li, JIN Hai, LI Changqing. Research Progress on Molecular Mechanism of miRNA and lncRNA Regulating Follicular Development in Ruminants [J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(2): 771-780.
[4]	XU Haotian, YU Yuetong, LI Jing, MA Zhiyuan, YANG Bin, WANG Zekun, TUO Haixin, QI Meng. Comparative Analysis of miRNA Expression Profiles in Bovine Mammary Epithelial Cells Treated with Lipopolysaccharide and Calcium Ions [J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(9): 4066-4079.
[5]	YAO Weijia, LUO Chunhai, LIU Jiajin, WANG Wei, LI Danyang, LIU Bingqi, FU Shixin. Effect of Overexpression of miRNA-424-5p Targeting AKT3 on Apoptosis of Endometrial Epithelial Cells in Dairy Cows [J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(8): 3635-3642.
[6]	LUO Chunhai, ZHENG Chengyuan, ZHANG Menglong, YAO Weijia, LIU Jiajin, LIU Bingqi, WANG Wei, FU Shixin. Regulation of Vascular Endothelial Growth Factor A Expression by miRNA-185 in Dairy Cows with Retained Fetal Membranes [J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(3): 916-925.
[7]	CHEN Bohe, LIUFU Sui, YU Zonggang, WANG Kaiming, LIU Xiaolin, YI Lei, MA Haiming. Research Progress on the Regulation of Non-coding RNA in Muscle Fiber-type Conversion in Animals [J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(3): 1132-1141.
[8]	LI Ying, GUO Xu, JIANG Qicheng, GU Lihong. Study on the Co-regulation of m⁶A and miRNA on Skeletal Muscle Development of Peking Ducks in Embryonic Stage [J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(2): 470-481.
[9]	LI Hongyi, YANG Xuefen, LIN Zesen, WU Xiaofei, LYU Qixin, YU Jiali, ZHANG Mao. Effect of Lactobacillus reuteri Replacing Antibiotics on the Expression of Intestinal miRNA in Piglets [J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(1): 74-85.
[10]	ZHANG Xinyu, WANG Dan, YANG Xia, FU Jiaqi, CAO Yang, ZHANG Lichun, SUN Fuliang. Differentially Expressed miRNAs Screening and Regulatory Network Analysis of Xinji Fine Wool Sheep and Small-tailed Han Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(9): 3480-3489.
[11]	REN Qiaoling, ZHANG Jiaqing, WANG Jing, CHEN Junfeng, MA Qiang, GAO Binwen, LIU Fujiu, XING Baosong. Comparison and Analysis of miRNA Expression Profile in the Hypothalamic-pituitary Axis of Anestrous and Estrous Primiparous Sows [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(11): 4491-4503.
[12]	HE Yue, CHEN Mengdi, BAI Jinhui, SONG Jixuan, XIA Guangjun. Research Progress on the Regulation of miRNA from Adipose-derived Exosomes on Lipid Metabolism [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(10): 3950-3958.
[13]	WANG Dong, LIANG Jiayue, WANG Xiaobing, FENG Juan, ZHANG Ru, XIA Huiyan, XIAO Hongmei. Research Progress of Non-coding RNA in the Development of Hair Follicles of Cashmere Goats [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1817-1827.
[14]	ZHANG Yuming, CHEN Qiaoguang, HOU Zhaofeng, LIU Dandan, TAO Jianping, XU Jinjun. Research Progress on Chicken miRNAs and Their Regulation Role After Pathogenic Infection [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1908-1916.
[15]	WANG Yueli, SHAO Zhiran, YI Jihai, WANG Yong, WANG Zhen, CHEN Chuangfu. miR-145a-3p Regulates Brucella Induced Mouse Macrophage RAW264.7 Autophagy by Targeting ATG14 [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 1117-1125.