China Animal Husbandry and Veterinary Medicine ›› 2022, Vol. 49 ›› Issue (6): 2129-2136.doi: 10.16431/j.cnki.1671-7236.2022.06.013

• Nutrition and Feed • Previous Articles     Next Articles

Effect of Mogrosides on Lipid Metabolism in Obese Mice

LIANG Yefei1,3, HUANG Panling1, LI Shuhui1, HUANG Guodong1, XIA Xing1, LI Yuqing1,2   

  1. 1. Key Laboratory of TCM Pharmacology of Guangxi University of Chinese Medicine-Education Department of Guangxi Zhuang Autonomous Region, Guangxi University of Chinese Medicine, Nanning 530200, China;
    2. College of Public Health and Management, Guangxi University of Chinese Medicine, Nanning 530200, China;
    3. Department of Clinical Pharmacy, Qinzhou First People's Hospital, Qinzhou 535000, China
  • Received:2021-12-27 Online:2022-06-05 Published:2022-05-27

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Abstract: 【Objective】 This study was aimed to investigate the effects of mogrosides on improving the lipid metabolism abnormality in obese mice caused by high-fat diet, and explore its mechanism of action.【Method】 60 healthy male Kunming mice were randomly divided into 6 groups after being fed with high-fat diet for 4 weeks, including normal group, model group, simvastatin group, and high (200 mg/(kg·d)), medium (100 mg/(kg·d)) and low (50 mg/(kg·d)) dose mogrosides groups.The mogrosides dose groups were administered by gavage for 4 weeks while maintaining high-fat feeding.After the administration was completed, the body weight of mice in each group and the weight of adipose tissue were obained, and the fat coefficient was calculated.The contents of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in serum and liver, the contents of apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) in serum, and the activities of lipoprotein lipase (LPL) and hepatic esterase (HL) in liver were measured.【Result】 Compared with blank group, the body weight, fat weight and fat coefficient of mice in model group were extremely significantly increased (P<0.01).Compared with model group, the fat weight and fat coefficient of mice in high and medium dose mogrosides groups were significantly reduced (P<0.05);The contents of TC and LDL-C in serum and liver of mice in high dose mogrosides group were significantly or extremely significantly reduced (P<0.05 or P<0.01), and the content of HDL-C in serum was extremely significantly increased (P<0.01);The content of ApoB in serum of mice in high and medium doses mogrosides groups was extremely significantly reduced (P<0.01), and the activities of LPL and HL in liver of mice were extremely significantly or significantly increased (P<0.01 or P<0.05).【Conclusion】 The mogrosides could prevent the increase of blood lipid, liver fat and body fat in obese mice induced by high-fat diet, its possible mechanism was by affecting the synthesis of ApoB and the activities of HL and LPL.The results provided a reference for the development of the mogrosides as a potential weight lowering and lipid lowering agent.

Key words: mogrosides; hyperlipidemia; lipid metabolism; obesity

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