MAP3K5基因在畜禽剩余采食量表型调控中的研究进展

doi:10.16431/j.cnki.1671-7236.2021.01.024

Abstract

Abstract: With the development of molecular genetics,a large number of quantitative trait sites and candidate genes that affect residual feed intake (RFI) have been identified.Mitogen-activated protein kinase 5 (MAP3K5),also known as apoptosis signal-regulating kinase 1 (ASK1),is one of the MAPK super family genes.Currently,there are extracellula signal-regulated protein kinase (ERK),c-Jun N-terminal kinase (JNK) and p38 mitogen-active protein kinase (p38-MAPK) the three members of the MAPK family were cloned and identified in mammalian cells,and their main biological mechanism was to mediate three MAPKs signaling pathways,thus affecting the growth,body size and milk production traits of livestock.In previous study of the residual feed intake in cattle,we screened out the MAP3K5 gene related to cattle RFI.Although the function of the MAP3K5 gene in cattle was not clear currently.Based on this,this article reviewed the structure and biological function of the gene,summarized the function and role of the gene in the main livestock and poultry feed intake variation and human obesity phenotype,and analyzed the MAP3K5 gene from the perspective of genetics.Possible mechanisms in the regulation of RFI phenotype in livestock and poultry.By reviewing the research progress of MAP3K5 gene in the regulation of livestock and poultry RFI phenotype,it was hoped to provide ideas for further research on the molecular mechanism of MAP3K5 gene in the regulation of livestock and poultry feed intake traits.For other possible effects of MAP3K5 gene on livestock and poultry phenotypic factors (such as intestinal flora) need to be further explored.

Key words: MAP3K5 gene; residual feed intake (RFI); feed intake (FI); feed efficiency; obesity

CLC Number:

DING Yanling, MA Ying, YANG Chaoyun, SHI Dandan, SHI Yuangang, KANG Xiaolong. Research Progress of MAP3K5 Gene in the Regulation of Residual Feed Intake Phenotype in Livestock[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(1): 218-225.

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Research Progress of MAP3K5 Gene in the Regulation of Residual Feed Intake Phenotype in Livestock

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