China Animal Husbandry and Veterinary Medicine ›› 2020, Vol. 47 ›› Issue (2): 460-468.doi: 10.16431/j.cnki.1671-7236.2020.02.017

• Animal Nutrition and Feed Science • Previous Articles     Next Articles

A Effects of Different Combinations of Antibiotic Substitute on Growth Performance, Diarrhea Rate and Antioxidant Indexes of Weaned Piglets

SUN Xiaojiao1,2, JIN Haifeng2, YAN Yan1, JIN Yi1, LI Xiangzi1   

  1. 1. College of Agriculture, Yanbian University, Yanji 133002, China;
    2. CJ China Feed Research Institute, Shenyang 110028, China
  • Received:2019-05-31 Published:2020-02-28

PDF (PC)

119

Abstract: To evaluate the possibility of substituting in-feed antibiotics with different combinations of substitute,240 crossbred piglets (Duroc×Landrace×Yorkshire) weaned at (28±3) days of age were selected and randomly assigned into 5 groups,the control group (basal diet),antibiotic group (basal diet＋75 mg/kg CTC+40 mg/kg bacitracin zinc+100 mg/kg olaquindox),treatment group 1 (basal diet＋2 000 mg/kg fermented Chinese herb),treatment group 2 (basal diet＋500 mg/kg clostridium butyricum+1 000 mg/kg tributyrin) and treatment group 3 (basal diet＋450 mg/kg Macleaya cordata extract+800 mg/kg betaine anhydrous).The trial had 5 replicates per group and 12 piglets per replicate,and lasted for 32 d.At the 14th and 32nd days,one pig was randomly selected from each replication,and the plasma samples were collected from the anterior vena cava.The growth performance,diarrhea rate,and plasma antioxidant indexes were measured.The results showed that:① From 1 to 14 d,compared with the control group,ADFI and ADG of weaned piglets in treatment group 3 were significantly increased (P < 0.05),and F/G was significantly decreased (P < 0.05).From 15 to 32 d,compared with the control and antibiotic groups,treatment group 3 could extremely significantly decreased F/G of weaned piglets (P < 0.01).From 1 to 32 d,compared with the antibiotic group,F/G in treatment group 3 was significantly decreased (P < 0.05).② From 1 to 14 d,treatment group 3 could extremely significantly decreased diarrhea index compared with the control group (P < 0.01).From 15 to 32 d and 1 to 32 d,diarrhea indexes of weaned piglets in treatment group 2 and 3 were extremely significantly lower than the control group (P < 0.01).The diarrhea index had no significant difference between the antibiotic group and treatment group 3 (P > 0.05),but they both decreased in some degree compared with the control group (P > 0.05).③ Compared with the control and antibiotic groups,in treatment group 3,at the 14th day,T-SOD and GSH increased significantly or extremely significantly (P < 0.05;P < 0.01),while MDA and H2O2 decreased significantly or extremely significantly (P < 0.05;P < 0.01).At the 32th day,GSH increased extremely significantly (P < 0.01),while MDA decreased significantly or extremely significantly (P < 0.05;P < 0.01).The results suggested that supplementation of Macleaya cordata extract (450 mg/kg) and betaine anhydrous (800 mg/kg) could improve the antioxidant capacity,decreased F/G and diarrhea rate.Its effect was superior to other combinations,and it could be used as the substitute for antibiotics in feed.

Key words: antibiotic; substitute; growth performance; diarrhea; antioxidant indexes

CLC Number: