非洲猪瘟病毒免疫及基因工程疫苗研究进展

doi:10.16431/j.cnki.1671-7236.2019.11.031

Abstract

Abstract: African swine fever (ASF) is an acute,hemorrhagic and highly contagious tiboviral disease in domestic pigs,caused by African swine fever virus (ASFV).The disease shows reticuloendothelial hemorrhage and high mortality,is one of arguably the most significant emerging disease threat for the swine industry worldwide.ASFV is a large DNA virus,with the complexity of the structure and the large number of proteins encoded by its genome.This review focuses on recent progress of the ASFV characteristics,mechanisms of immune response including immune escape,humoral immunity,and cellular immunity,genetic engineering vaccines including live attenuated vaccines,subunit vaccines,live virus vector vaccines and DNA vaccines.Finally,the vaccine development and prevention and control-eradiction strategies of ASF in China are prospected.

Key words: African swine fever virus (ASFV); apoptosis; autophagy; immune response; genetic engineering vaccines

CLC Number:

S852.65⁺1

MA Xingshu, SONG Jinxiang. Research Progress on Immune Response and Genetic Engineering Vaccines Against African Swine Fever Virus[J]. China Animal Husbandry and Veterinary Medicine, 2019, 46(11): 3404-3413.

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Research Progress on Immune Response and Genetic Engineering Vaccines Against African Swine Fever Virus

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