Abstract: Self-biting is the frequent diease to furriery animal such as mink,fox,which affect on the furriery qualities. The reason isn’t definite.Primarily discuss the reason from molecule genetics.Constract the group of health and self-biting with RAPD (random amplified polymorphic DNA，RAPD)，randomly select 40 polymorphisms primers which are good reproducibility. Abstract 40 DNA from each group,and random construction gene cistem from 10 DNA. Primer S103(sequence is AGACGTCCAC) with obviouslily difference from health and selfbiting is selected,and clone,send the result of clone to Sangon biologic company in shanghai to sequence. Through primer S103, only in the disease mink groups we amplify 750 bp DNA fragment, 600 bp DNA is showed up in the health group but disease group isn't. So this can serve as molecular genetic labeling to distinguish from healthy and sick mink groups. So the different fragments both primarily distinguish the molecular genetic labeling from health and diease,it bases on the deeply study for the self-biting.

Key words: mink; self-biting; molecular; genetic