生物信息学在黄曲霉毒素B1毒性机制研究中的应用

doi:10.16431/j.cnki.1671-7236.2025.04.017

Abstract

Abstract: Aflatoxin B₁(AFB₁) is a kind of natural toxin,widely found in food and animal feed,with strong acute toxicity,carcinogenicity,teratogenicity and mutagenicity,posing a huge risk to human and animal health.Animal ingestion of AFB₁-contaminated feed causes immunosuppression,reproductive disorders,organ damage and even large-scale death,causing great economic losses to the animal husbandry industry.In addition,AFB₁ is transferred to animal-derived foods such as meat,eggs and milk through feed,and eventually enters the human body through the food chain,causing acute or chronic poisoning and endangering human health.Bioinformatics is an interdisciplinary discipline that integrates computer science,biology and statistics,and obtains,processes,analyzes and interprets biological information through a combination of multi-field research methods.Bioinformatics analysis methods,including network toxicology,transcriptomics,proteomics and metabolomics are the cutting-edge technologies in the field of life sciences and an important tool and technique to elucidate the mechanism of toxicity.The authors focuse on the application of bioinformatics in the mechanism of AFB₁ toxicity,aiming to provide an effective approach and theoretical basis for the prevention and treatment of AFB₁ poisoning and the application of bioinformatics.

Key words: aflatoxin B₁; bioinformatics; toxicity mechanism; transcriptomics; metabolomics

CLC Number:

S852.4⁺4

LIU Xiaotong, GE Bingjie, QIU Qian, LIU Xinman, YU Minghong, ZHANG Xuemei. Application of Bioinformatics in Toxicity Mechanism of Aflatoxin B₁[J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(4): 1639-1650.

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Application of Bioinformatics in Toxicity Mechanism of Aflatoxin B₁

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Application of Bioinformatics in Toxicity Mechanism of Aflatoxin B1

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Application of Bioinformatics in Toxicity Mechanism of Aflatoxin B₁