Abstract: Antimicrobial peptides have become potential drugs to replace antibiotic for preventing and controlling diseases,but it's still lack of suitable mass production conditions because of low yield and high production cost,so it becomes inevitable to use gene engineering technology of antimicrobial peptide reconstruction.This paper analyzed the research status of antimicrobial peptides,concluded the gene transformation strategies,such as amino acid residues design,peptide fragments junction and construction of peptide cyclization,computer aided design,the target design and simulation of biological model,and the advantage of gene recombination technology by fusion expression,tandem expression and multi copy expression.This research progress would lay theoretical foundation for low cost and large scale production of antimicrobial peptides.

Key words: antimicrobial peptides; molecular design; gene recombination; expression regulation; research status