过氧化物酶体增殖物激活受体γ辅激活因子1α与肌纤维类型转化及其表达调控研究进展

doi:10.16431/j.cnki.1671-7236.2015.10.019

Abstract

Abstract: Peroxisome proliferators-activated receptor-γ (PPAR-γ) coactivator-1α (PGC-1α) is a versatile transcriptional regulator.PGC-1α is characteristically involved in the regulation of several crucial cellular pathways including mitochondrial biogenesis,fatty acid oxidation,gluconeogenesis and so on.PGC-1α is significantly associated with meat quality,since it may affect the fiber-type switching through several signaling pathways in livestock and poultry.Therefore,study on PGC-1α expression regulation in the transcription and post-translation level can provide new strategies for improving the meat quality.In recent years,the effect of dietary nutrition on PGC-1α has been also researched gradually for its importance in the regulation on meat quality in livestock and poultry.This review described the structure and expression patterns in tissues of PGC-1α,and its regulatory mechanism on muscle fiber-type switching,focusing on recent advances on its expression regulation in the transcription and post-translation level,also summarized the effect of dietary nutrition on PGC-1α.

Key words: PGC-1α; muscle fiber-type; transcription level; post-translation level; expression regulation; nutrition

CLC Number:

S828

ZHOU Zhao-hong, CHEN Dai-wen, TIAN Gang, XIAO Zhu-hong, YU Bing. Research Progress on the Relationship between Peroxisome Proliferators-activated Receptor-γ Coactivator-1α and Muscle Fiber-type Switching,and its Expression Regulation[J]. , 2015, 42(10): 2636-2643.

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Research Progress on the Relationship between Peroxisome Proliferators-activated Receptor-γ Coactivator-1α and Muscle Fiber-type Switching,and its Expression Regulation

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