动物氨基酸转运载体的研究进展

doi:10.16431/j.cnki.1671-7236.2020.03.012

Abstract

Abstract: The amino acid transporter is an important protein that mediates the transport of amino acids from the outsides to the inside of cells and also is an crucial nutrient-sensing molecule that can regulate amino acid-related signaling pathways,which has significant effects in many aspects,including body's growth and metabolism,nutrition and health.There are many types of AAT in animal organisms that can sense changes of amino acid levels in the body,mediating cellular amino acid sensing signaling pathways-mammalian rapamycin target protein complex 1 (mTORC1) and general control nonderepressible 2(GCN2) to active,which causes the downstream of the hair pathway to function.The leading AAT exists diversity in different tissues,indicating that AAT is tissue-specific,simultaneously,AAT is also affected by many factors,such as the animal body itself,nutrient levels,hormone levels,and so on.This review focuses on four aspects to understand AAT macroscopically,including the types and transport mechanisms of AAT,mediating the initiation of nutrient signaling、mTORC1 pathway and GCN pathway,the role of ATT in different tissues,and the regulation of AAT expression,in order to provide some useful knowledge for AAT research.

Key words: amino acid transporter; nutritional signal; mTORC1; GCN

CLC Number:

Q493

HE Yue, ZHAO Shengguo, LUO Chaochao, ZHENG Nan, WANG Jiaqi. Research Progress on Animal Amino Acid Transporter[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(3): 744-753.

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Research Progress on Animal Amino Acid Transporter

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