乳酸菌活载体疫苗研究进展

Abstract

Abstract: Lactic acid bacteria have been widely used as the vehicle to deliver various pathogen antigens for their advantage, such as probiotic, adjuvant effect, simple preparation, and low production cost. Live vaccine with lactic acid bacteria as the delivery vector is now one hot vaccine research field, for they can stimulate the humoral, mucosal, and cellular immune responses at the same time. In this paper, the mechanism and the way to deliver heterogenous antigen of this kind of live vaccine were generalized, the application of them in preventing viral, bacterial, and parasitic diseases was discussed, and the existed problem and prospect in application were finally analyzed and forecasted.

Key words: lactic acid bacteria; live vector; vaccine; mucosal immune

CLC Number:

Q939.9

CAO Hai-peng, WANG Hong-ning, ZHANG An-yun, YANG Xin, MA Bing-cun, XU Peng-wei, DING Meng-die. Research Progress of Lactic Acid Bacteria as Live Vaccine Vehicle[J]. , 2014, 41(9): 258-264.

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