›› 2014, Vol. 41 ›› Issue (9): 154-157.

Previous Articles     Next Articles

Research Progress on Effect of 5-hydroxytryptamine on the Barrier of Intestinal Mucosal Epithelial Cell

SONG Jin-yuan1, YANG Chen-yu1, WANG Zi-xu1, CHEN Yao-xing1, QIN Zhuo-ming2, HAN Ya-nan1, DONG Yu-lan1   

  1. 1. College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;
    2. Institute of Poultry, Shandong Academy of Agricultural Sciences, Jinan 250100, China
  • Received:2014-02-12 Online:2014-09-20 Published:2014-09-24

Abstract: 5-hydroxytryptamine (5-HT), as an essential neurotransmitter and intercellular messenger, has a variety of biological functions. More than 90% of 5-HT is localized in the gastrointestinal system where 5-HT plays an important role. The occurrence of many intestinal diseases is associated with the changes of 5-HT expression. 5-HT affects proliferation and maintenance of intestinal mucosal epithelial cell, increases intestinal permeability, and promotes goblet cell to release mucus indirectly. The mechanism of those actions may be that 5-HT stimulates afferent neuron and then activates the secretion of vasoactive intestinal peptide (VIP) and acetylcholine (ACH), thus causes diarrhea. For the purpose of giving some guiding information of diagnosing and treating intestinal diseases, the article discussed the reason of 5-HT causes diarrhea and the effect of 5-HT on the barrier of intestinal mucosal epithelial cell.

Key words: 5-HT; intestinal mucous membrane; intestinal diseases

CLC Number: