抗精神分裂症药物对吐鲁番斗鸡5-HTT和TPH1基因表达的影响

doi:10.16431/j.cnki.1671-7236.2018.02.028

Abstract

Abstract:

In order to investigate the molecular mechanism of different antischizophrenic drugs on the aggressive behavior of Turpan cockfighting. A total of 36 cockfightings were randomly divided into 12 groups,and four antipsychotic drugs of risperidone,aripiprazole,trazodone hydrochloride,sertraline hydrochloride were selected,and each drug was given a low dose group (L),normal dose group (N) and high dose group (H) with daily artificial oral medication. Respectively,at the 1,2,5,8,11 and 14 days,the blood samples were collected from wing vein,and the mRNA expression of 5-HTT and TPH1 genes in the blood of Turpan cockfighting at various stages of oral administration in different drugs doses were measured by quantitative Real-time PCR. The results showed that the expression change of 5-HTT and TPH1 genes mRNA in the blood of the risperidone group and aripiprazole group were similar. The overall 5-HTT gene showed a downward trend,and the TPH1 gene showed increased volatility,and the expression of TPH1 gene mRNA in risperidone group was higher than that in aripiprazole group.The expression of 5-HTT gene mRNA in the trazodone hydrochloride group and sertraline hydrochloride group increased linearly from the 5th day and peaked at the 14th day, and the TPH1 gene in the sertraline hydrochloride group was slightly up-regulated,but there was no obvious change in the trazodone hydrochloride group. It was suggested that the molecular influencing factors of the decrease in the aggressive behavior of risperidone and aripiprazole groups were related to the low expression of 5-HTT gene in the blood,and the results of this study could provide an important reference for further study on the molecular mechanism of the drug affecting the aggressive behavior of Turpan cockfighting.

Key words: Turpan cockfighting; aggressive behavior; antischizophrenic drugs; 5-HTT gene; TPH1 gene

CLC Number:

Q786

ZHANG Mei, ZHANG Miaomiao, LI Yan, ZHANG Lu, LIU Xiuxia, LI Yidan, ZHONG Xinxian, LI Yingsheng, LI Haiying, CHANG Guobin, CHEN Guohong, LIAO Herong. Effects of Antipsychotic Schizophrenia Drugs on the Expression of 5-HTT and TPH1 Genes in Turpan Cockfighting[J]. , 2018, 45(2): 510-517.

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Effects of Antipsychotic Schizophrenia Drugs on the Expression of 5-HTT and TPH1 Genes in Turpan Cockfighting

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[1]	LI Yi-dan, LIU Xiu-xia, LI Ying-sheng, WANG Lei, JIA Wei, LI Xing-ming, ZHONG Xin-xian, LI Yan, LIAO He-rong. Establishment of Turpan Gamecock Aggression Behavior Spectrum and SNP Analysis of Monoamine Oxidase A Gene [J]. , 2014, 41(3): 182-187.
[2]	HUANG Fang-fang;LI Xiang;LI Jian-hong. Analysis on Influence Factors of Animal Aggressive Behavior [J]. , 2011, 38(6): 239-243.
[3]	ZHANG Jin-cheng;HAN Guang;LIAO He-rong. he Research Development of Animal Aggressive Behavior [J]. , 2009, 36(4): 196-200.