卡介菌多糖核酸对新城疫疫苗免疫雏鸡抗氧化及免疫活性的影响

Abstract

Abstract: Polysaccharide nucleic acid fraction of Bacillus Calmette Guerin (BCG-PSN) was applied on chicken immuned by Newcastle disease (ND) vaccine to observe the influence on antioxidation and immune activities. Two hundreds 1-day-old AA chicken were randomly divided into 5 groups，BCG-PSN high dose (0.12 mg per chick), medium dose (0.06 mg per chick), low dose (0.03 mg per chick) groups, Astragalus polysaccharide group (APS, positive group, 0.06 mg per chick) and control group with 40 chicken each group. All chicken were injected with drugs for 7 days according to the group and immuned by ND vaccine in 7 days old, while the control group was injected with physiological saline instead. Chicken were killed after 5,10,15,20 days injection, and thymus, spleen, bursal and jugular vein blood were collected, while immune organ index, NDV antibody titer, SOD, LPO, GSH-Px, IgG and IgM were tested. The results showed that BCG-PSN could not only significantly increase the activities of SOD and GSH-Px while significantly reduce the concentration of LPO (P＜0.05) which indicated a good function of antioxidation, but also significantly increase the immune organ index, NDV antibody titer, concentrations of IgG and IgM in serum (P＜0.05) which indicated an effect of immune adjuvant.

Key words: BCG-PSN; chicken; antioxidation; immune activity

YU Min, WANG Hai-bo, MENG Ting, GAO Yue-xiu, DING Xiao-li, DONG Ya-qing. Effect of BCG-PSN on Antioxidation and Immune Activity of Chicken Immuned by Newcastle Disease Vaccine[J]. .

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Effect of BCG-PSN on Antioxidation and Immune Activity of Chicken Immuned by Newcastle Disease Vaccine

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