艰难梭菌毒素致病机理的研究进展

Abstract

Abstract: Clostridium difficile is a G⁺ anaerobic and one of the most important pathogenic bacteria in human intestinal infection. Its major pathogenic factors are toxin A (enterotoxin) and toxin B (cytotoxin).After the cell damage caused by toxin A, toxin B can invade the intestinal mucosa, cause cell lesion, lead to cytopathy and a series of clinical manifestations in infection.Meanwhile, Clostridium difficile toxin is also an important factor causing diarrhea in pigs, chickens and other livestock. Exploring the damage of Clostridium difficile toxin to the body is helpful to reveal the pathogenesis of Clostridium difficile, which provides a theoretical basis for prevention and control of Clostridium difficile.

Key words: Clostridium difficile; toxins; damage; pathogenesis

CLC Number:

S852.61⁺6.3

NI Meng-ying, WU Chang-de, YANG Jing-xue. Research Progress on the Pathogenesis of Clostridium difficile Toxins[J]. , 2014, 41(12): 263-267.

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Research Progress on the Pathogenesis of Clostridium difficile Toxins

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