Abstract: Hyperlipidemia,as one of the most common diseases in large-scale donkey breeding farms,has the characteristics of high morbidity,high mortality and difficult early diagnosis,which seriously harms the healthy development of China’s donkey industry.The underdeveloped pathway of ketone body production in donkeys,coupled with multiple factors such as innate insulin resistance,makes them more susceptible to hyperlipidemia.This disease is caused by excessive mobilization of adipose tissue due to a negative energy balance which can be divided into primary hyperlipidemia caused by stress,obesity,pregnancy,lactation and genetics,as well as secondary hyperlipidemia caused by various systemic diseases that contribute to the negative energy balance of the body.Its etiology and mechanism mainly include blood lipid accumulation,tissue resistance to insulin,primary disease,intestinal flora disorder and genetic effects.The disease can be diagnosed by measuring the concentration of serum lipids combined with its clinical manifestations.With the development of metabonomics,we can also make a more accurate early diagnosis of hyperlipidemia by looking for relevant small molecular biomarkers combined with the concentration of serum triglycerides.The author reviewed the etiology,mechanism and clinical diagnosis methods of donkey hyperlipidemia,and prospected the future direction of donkey hyperlipidemia research,in order to promote the clinical diagnosis and treatment of donkey hyperlipidemia and the development of disease resistance breeding technology.

Key words: hyperlipidemia; negative energy balance; fat mobilization; pathogenesis; clinical diagnosis; biomarkers