组蛋白乙酰化修饰及其在DNA损伤修复调控作用中的研究进展

doi:10.16431/j.cnki.1671-7236.2025.04.005

Abstract

Abstract: Histone acetylation,as a delicate epigenetic modification mechanism,plays a crucial regulatory role at many levels of life.This modification not only regulates the expression level of genes and the three-dimensional spatial structure of chromatin,but also plays an indispensable role in DNA damage repair,a core biological process.The DNA damage repair process is a complex biological response that cells use to remove harmful errors or damage within the DNA molecule,ensuring the integrity and functionality of the genome.The repair process involves a variety of different pathways,such as direct repair (DR),base excision repair (BER),nucleotide excision repair (NER),mismatch repair (MMR),and double strand break repair (DSBR),etc.DNA double-strand breaks (DSBs) are the most common and have the greatest impact on genome stability.With the deepening of research,it has been found that histone acetylation can participate in multiple repair pathways by affecting the recruitment and activity of enzymes related to DNA damage repair,thereby dynamically maintaining genome stability at the epigenetic level.In order to better understand the role of histone acetylation in DNA damage repair,the types of DNA damage were classified,and the histone acetylation sites related to them were sorted out,focusing on the regulatory role of histone H3 and H4 acetylation sites in DNA damage repair,which provided a reference for the regulation and research of related cell phenotypes.

Key words: histone; acetylation modification; deacetylation modifications; DNA damage repair; apparent modification

CLC Number:

S813.1

LIANG Jiahao, SHI Yuangang, KANG Xiaolong. Research Pogress on Histone Acetylation Modification and Its Role in the Regulation of DNA Damage Repair[J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(4): 1499-1510.

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Research Pogress on Histone Acetylation Modification and Its Role in the Regulation of DNA Damage Repair

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