板蓝根多糖对缺乳仔鼠免疫器官发育及T淋巴细胞亚群的影响

Abstract

Abstract: Using the flow cytometry to detect CD3⁺,CD4⁺and CD8⁺ T lymphocyte levels of the lacking milk renewal rats to study the effect of different doses of RIP on immune organic devetopment and T lymphocyte subsets in lacking milk renewal rats. The results as follows,①RIP could increase the thymus gland index and spleen index of the lacking milk renewal rats. The doses of RIP which had the best effectiveness in the thymus gland and spleen index were decreased by the days. ②RIP could raise the numbers of CD3⁺,CD4⁺and CD8⁺ T cells in the lacking milk renewal rats. 7 to 28 days of age, the numbers of CD3⁺ T cells in the A,C and D groups were significantly different from those in B group (P<0.05). 7 to 21 days of age, the numbers of CD4⁺ T cells in the A,C and D groups were significantly different from those in B group (P<0.05). The numbers of CD3⁺,CD4⁺,CD8⁺ T cells and CD4⁺/CD8⁺vaules in each group were decreased by the days. This study indicated that certain dose of RIP could promote immune organic development in lacking milk renewal rats, and increase the level of T lymphocyte subsets.

Key words: indigowoad root pblysaccharides (RIP); lacking milk renewal rats; immune organ; T lymphocyte subsets

CLC Number:

S852.4

ZHANG Ting-ting, TAO Meng-jie, HUANG Peng, ZHANG Xue-wu, XIAO Chuan-bin. Effects of RIP on the Immune Organic Development and T Lymphocyte Subsets in Lacking Milk Renewal Rats[J]. , 2013, 40(8): 97-101.

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Effects of RIP on the Immune Organic Development and T Lymphocyte Subsets in Lacking Milk Renewal Rats

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