香附酮抑制鸡致病性大肠杆菌诱导肺泡Ⅱ型上皮细胞炎症作用的研究

Abstract

Abstract: The effects of cyperone on chicken alveolar epithelial type Ⅱ cells infected by APEC-O78 were evaluated through determining TNF-α, IL-10, TLR-4 and TLR-5 in vitro. The results showed that 0.5 μg/mL cyperone significantly decreased the secretion of TNF-α(P<0.05). 1 μg/mL cyperone extremly significantly increased IL-10 secretion(P<0.01). Furthermore, 0.1, 0.5 and 1 μg/mL cyperones all extremly significantly decreased the expression of TLR-4 mRNA(P<0.01), but had no effect on the expression of TLR-5 mRNA(P>0.05). The results indicated that cyperone might inhibit the production of inflammatory cytokines of chicken alveolar epithelial type Ⅱ cells induced by APEC-O78 through blocking TLR-4 signaling pathway.

Key words: cyperone; APEC-O78; chicken alveolar epithelial type Ⅱ cells; inflammation; signaling pathway

CLC Number:

S852.61⁺4

ZHANG Li-yan, GUO Xun, XIA Fang, HU Xi-rou, QIN Qian-qian, ZHANG Cui, SONG Zhou, SHEN Hai-qing, YI Peng-fei, WEI Xu-bin, FU Ben-dong. Inhibitory Effect of Cyperone on Inflammation of Chicken Alveolar Epithelial Type Ⅱ Cells Induced by APEC[J]. , 2013, 40(8): 92-96.

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Inhibitory Effect of Cyperone on Inflammation of Chicken Alveolar Epithelial Type Ⅱ Cells Induced by APEC

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