信号转导与转录激活因子5的结构与功能研究进展

Abstract

Abstract: Signal transducer and activator of transcription 5 (STAT5) was an important signal transducer and activator of transcription, and could be activated by a plethora of cytokines and polypeptide hormones resulting in transcriptional activation of specific target genes. It participated in the regulation of proliferation, differentiation and apoptosis of cell and played an important role in growth, hematopoiesis and immunological response. Furthermore, the activity of STAT5 was related to occurrence and development of tumor. This review summarized the structure and biological functions of STAT5.

Key words: signal transducer and activator of transcription 5; structure; biological function

CLC Number:

Q288

FU Zhi-ling, YANG Yan-hong, LI Wei, LAN Hai-nan, LIU Yu, GUO Feng, ZHAO Xue, ZHANG Hui, ZHENG Xin. Research Progress on the Structure and Function of Signal Transducer and Activator of Transcription 5[J]. , 2013, 40(10): 86-89.

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Research Progress on the Structure and Function of Signal Transducer and Activator of Transcription 5

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