苏尼特羊拷贝数变异的基因组分布特征研究

Abstract

Abstract: In this study, 71 Sunite sheep were genotyped using Illumina OvineSNP50 BeadChip array, a total of 134 CNV regions (CNVR) across the genome were identified, which covered 25.95 Mb of the sheep genome.CNVR size on autosomes range from 29.48 kb to 1.30 Mb. Functional indicated that the most genes overrepresented in environmental responses, which involved in sensory perception of smell, sensory perception of chemical stimulus, sensory perception, cognition. To confirm these findings, quantitative PCR (qPCR) was performed for 5 CNVR and 3 of them were successfully validated. Our findings would be of help to understand the sheep genome and provide preliminary foundation for investigating the association between important economic traits and CNV.

Key words: Sunite sheep; genome; copy number variation; single nucleotide polymorphism

CLC Number:

LIU Jia-sen, ZHANG Li, LI Yun-hua, ZHAO Fu-ping, WEI Cai-hong, DU Li-xin. Genomic Characteristics of Copy Number Variations in Sunite Sheep[J]. , 2013, 40(10): 173-178.

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Genomic Characteristics of Copy Number Variations in Sunite Sheep

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