糖原合成激酶抑制剂在胚胎干细胞自我更新中的作用

Abstract

Abstract: Embryonic stem (ES) cells are derived from the inner cell mass of early blastocyst, and possess the ability of self-renewal and maintenance pluripotency. Wnt signaling pathway plays important roles in maintaining self-renewal of ES cells. Glycogen synthase kinase-3 (GSK-3) inhibitors can active Wnt signaling pathway,then promote the self-renewal and cell-to-cell adhesion of ES cells. In this paper, we take a review for the effect and mechanism of GSK-3 inhibitors on maintaining self-renewal and cell-to-cell adhesion of ES cells.

Key words: embryonic stem cells; Wnt; glycogen synthase kinase-3; 6-bromoindirubin-3’-oxime; CHIR99021

CLC Number:

Q813.7

LAO Yan-ping, KE Hao, SUN Hong-liang, LIU Rong-li, MA Yu-jie, RUAN Qiu-yan, LEI Chuan, LU Feng-hua, LI Xiang-ping, SHI De-shun. Effect of Glycogen Synthase Kinase-3 Inhibitor on Maintaining Self-Renewal of Embryonic Stem Cells[J]. , 2013, 40(10): 134-139.

References

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Effect of Glycogen Synthase Kinase-3 Inhibitor on Maintaining Self-Renewal of Embryonic Stem Cells

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