Abstract: Comparing the difference of dissolution rate and total dissolution of icarii and flavonoids in different size herba epimedii. The icarii and flavonoids in the herba epimedii were determined by HPLC and UV spectrophotometer. The results showed that the dissolution rate and total dissolution of icarii and flavonoids in herba epimedii were increased when the size was more slim, and the dissolution of 400 mesh was the most. Compared with 300 mesh, the dissolution rate and total disslution of 500 mesh were reduced. Therefore, the 400 mesh was the best for herba epimedii.

Key words: herba epimedii; icarii; flavonoids; dissolution; HPLC; ultraviolet spectroscopy(UV)