不同佐剂的奶牛乳房炎多联苗对小鼠免疫机能的影响研究

Abstract

Abstract: This study was performed to investigate the effects of two adjuvants (aluminum hydroxide gel and propolis) multiple vaccines for cow mastitis immunization on mice. Rosette-forming cells (E-RFC) and lymphocyte transformation rate (LTR) of mice were chosen for immune response analysis after immuned at 7, 14, 21, 30 and 45 d, respectively. The results showed that the cellular immune level was improved significantly by both aluminum hydroxide gel and propolis, and reached peak at 30 d (P<0.01). However, at 30 and 45 d, propolis group showed the extremly higher E-RFC and LTR level than aluminum hydroxide gel group (P<0.01), which meaned that propolis, compared with aluminum hydroxide gel, could induce stronger sensitization degree of the multiple vaccines to T cell in mice. This study could provide scientific data for elucidating the immunization principle of multiple vaccines and screening the suitable adjuvant for vaccine.

Key words: cow mastitis; multiple vaccines; adjuvants; immune

CLC Number:

S852.4

LI Hong-sheng, LUO Jin-yin, WANG Xu-rong, LI Xin-pu, YANG Feng, YU Jie, XU Ji-ying, YAN Zuo-ting. Research of the Effects of Different Adjuvants Multiple Vaccines for Cow Mastitis Immunization on Mice[J]. China Animal Husbandry & Veterinary Medicine, 2013, 40(1): 149-152.

References

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Research of the Effects of Different Adjuvants Multiple Vaccines for Cow Mastitis Immunization on Mice

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