柔嫩艾美耳球虫癸氧喹酯耐药株的诱导研究

Abstract

Abstract: The resistance of Eimeria tenella against the anticoccidial drug decoquinate was induced experimentally. The initial concentration of decoquinate was 5.4 mg/kg, E. tenella was serially passaged in chickens with gradually increasing concentration of decoquinate, and it took 9 passages to produce the drug-resistant strain of E. tenella to 54 mg/kg decoquinate. The drug resistance was assessed by RLS (reduction of lesion scores), POAA (percentage optimum anticoccidial activity) and ACI (anticoccidial index). These results of this study would provide foundation and materials for further molecular biological studies of the mechanism of drug resistance.

Key words: Eimeria tenella; decoquinate; drug-resistance; chicken

CLC Number:

S852.72

PAN Hong, LIN Rui-qing, SHU Li, CHENG Tian, LIU Guo-chang, WANG Xin-qiu, WENG Ya-biao. Experimental Induction of Drug-resistant Strains of Eimeria tenella against Decoquinate[J]. .

References

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Experimental Induction of Drug-resistant Strains of Eimeria tenella against Decoquinate

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