哺乳动物DNA甲基化研究进展

Abstract

Abstract: DNA methylation is the common base modification in the eukaryotic genome and is an important epigenetic mechanism. Methylation at the five-carbon of cytosine is a reversible process that can directly influence gene activity and the reaction is catalyzed by a family of DNA methyltransferases(DNMTs). DNA methylation is essential for normal mammals development and plays an important role in the affects a wide range of essential biological processes,and it includes silencing of transposable elements,inactivation of genes,maintenance of chromosomal integrity,X chromosome inactivation,and transcriptional regulation of a large number of genes and so on.

Key words: DNA methylation; DNA methyltransferases; epigenetic; silencing

CLC Number:

YANG Chun, XING Xiu-mei. Research Progress on the Methylation in Mammals[J]. .

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Research Progress on the Methylation in Mammals

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