蛋氨酸对动物表型性状的影响及DNA甲基化调控机制的研究进展

doi:10.16431/j.cnki.1671-7236.2019.04.018

Abstract

Abstract:

Methionine (Met) is an important methyl donor in the growth and metabolic process of animal.At the same time,as the only sulfur-containing amino acid in the essential amino acid,it is the first or second restrictive amino acid with lysine to synthesize corn-soybean meal feed or microbial protein.In addition,Met serving as a feed additive plays an important role in animal production performance,autoimmunity and disease prevention.With the development of epigenetics in the field of animal studies,as an important nutrient,Met can be used to carry out epigenetic modifications (DNA methylation,histone modification,chromatin remodelling and non-coding RNA,etc.).DNA methylation is one of the ways of epigenetics,and it has an important role in the study of phenotypic traits,making it a connection between genes and phenotypes.This paper introduces the mechanism of DNA methylation and the regulation of methionine metabolism,which will provide references for understanding the relationship between the Met and epigenetic modification and further revealing the molecular mechanism of phenotypic traits.In addition,through genomics,further prospect and analysis of how Met affects the changes of animal phenotypic traits at the molecular level can also help grasp the individual differences in animal Met demands,determine the individual nutritional requirements,and realize the real "gene breeding" model.

Key words: methionine (Met); epigenetics; DNA methylation; phenotypic traits

CLC Number:

S813.1

XU Youxin, LI Zongzhen, WANG Jie, ZHANG Naifeng. Research Progress on Effects of Methionine on Phenotypic Traits and Regulation Mechanism of DNA Methylation in Animals[J]. , 2019, 46(4): 1108-1115.

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Research Progress on Effects of Methionine on Phenotypic Traits and Regulation Mechanism of DNA Methylation in Animals

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