阳离子抗菌肽的杀菌及抗药性机制的研究进展

Abstract

Abstract: Cationic antimicrobial peptides were a class of small peptides with anti-extrogenous pathogen invasion. As an important component of congenital immune defense system against infections, they were widely distributed in vivo. It exhibited potent and broad-spectrum activities against both Gram-positive and Gram-negative bacteria, fungi, viruses, protozoa, and cancer cells,and normal eukaryotic cells with low toxicity. It was an ideal alternative to a new generation of antibiotics. However, the same as antibiotics, some bacteria were resistant to certain antimicrobial peptides. The antibacterial and drug-resistant mechanism of the cationic antimicrobial peptides were summarized in the article to provide certain reference.

Key words: cationic antimicrobial peptides; bacteria; antimicrobial mechanism; mechanisms of resistance

CLC Number:

HONG Jun, HU Jian-ye. Research Progress on Cationic Antimicrobial Peptides in Antibacterial and Drug-resistant Mechanism[J]. , 2012, 39(11): 140-144.

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Research Progress on Cationic Antimicrobial Peptides in Antibacterial and Drug-resistant Mechanism

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