重组人干扰素α1b喷雾剂皮肤局部药代动力学研究

Abstract

Abstract: To study the skin pharmacokinetics of interferon α1b spray, the pharmacokinetics of interferon α1b spray on the skin was carried out in the integral, permeable and injured skin of the minipigs. 1, 3, 5, 25 μg/mL of recombinant human interferon α1b were consperged onto animal’s skin. Skin tissues were shearing and homogenated at 0,1,2,4 h after consperge. The biological activity of interferon α1b was measured to show the drug’s antiviral effect. The interferon α1b was detected in integral skin and achieved to therapeutic concentration in permeable and injured skin of minipigs within 4 h after consperging; the concentrations of interferon α1b in tissues were correlated with dosage and time, those differences between groups were significant (P<0.05). 5 μg/mL interferon α1b spray showed antiviral effect on skin region when sprayed every 4 h.

Key words: interferon α1b; spray; skin; pharmacokinetics; minipig

CLC Number:

S859

ZHAN Da-wei, NIU Chun, YAN Ke-song, LI Jie, XU Chen, LIU Jin-yi. Study on Skin Region Pharmacokinetics of Recombinant Human Interferon α1b Spray[J]. , 2012, 39(10): 163-165.

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Study on Skin Region Pharmacokinetics of Recombinant Human Interferon α1b Spray

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