游泳应激对小鼠肾脏、肺脏和脑组织脂质过氧化状态的影响

Abstract

Abstract: In order to research the effects of swimming stress on lipid peroxidation of kidneys, lungs and brain tissues in mice. 50 Kunming mice were conducted the swimming experiment, 10 mice selected randomly were sacrificed before swimming and at 10, 20, 30, 50 min after swimming respectively, kidneys, lungs and brain tissues of mice were collected, maleic dialdehyde (MDA) contents, superoxide dismutase (SOD) activities and glutathione peroxidase (GSH-Px) activities were determined by spectrophotometry. This results showed that MDA contents of kidneys, lungs and brain tissues of mice at 10 or 20 min after swimming were increased significantly (P<0.05), and then decreased in a different extent; SOD activities of kidneys during the swimming process continued to rise, and 30 and 50 min groups significantly increased (P<0.05), SOD activities of lungs at 20 min after swimming reduced markedly (P<0.05) and increased slightly at 30 min after swimming, a little decrease was found at 50 min after swimming again, SOD activities of brain tissues were no significant difference during the whole swimming progress; GSH-Px activities of kidneys at 20 and 30 min after swimming significantly increased (P<0.05) and decreased markedly at 50 min after swimming(P<0.05), GSH-Px activities of lungs during the first 40 min swimming process continued to decrease and significantly reduced at 30 min swimming group (P<0.05), GSH-Px activities of brain tissues at 10 and 20 min after swimming significantly decreased (P<0.05) and then fluctuant changes occured. These results indicated that lipid peroxidation of kidneys, lungs and brain tissues in mice was affected by swimming stress and speculated that swimming stress may cause lipid peroxidation reaction of the whole body of mice.

Key words: swimming stress; mice; kidneys; lungs; brain tissues; lipid peroxidation

CLC Number:

S815

LI Liu-an, PENG Feng, YANG Feng. Effects of Swimming Stress on Lipid Peroxidation of Kidneys, Lungs and Brain Tissues in Mice[J]. , 2012, 39(10): 159-162.

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Effects of Swimming Stress on Lipid Peroxidation of Kidneys, Lungs and Brain Tissues in Mice

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