羊布鲁氏菌甲酰基转移酶的生物信息学研究

China Animal Husbandry & Veterinary Medicine ›› 2011, Vol. 38 ›› Issue (7): 123-126.

• 生物技术 • Previous Articles Next Articles

Bioinformatics Analysis of Formyltransferase of Brucella melitensis

WANG Jing-long^1,2, WANG Xing-long^2,3

1. College of Animal Science and Veterinary Medicine,Heping Campus,Jilin University,Changchun 130062,China;2. Institute of Military Veterinary,Academy of Military Medical Sciences of PLA,Changchun 130062,China;3. Key Laboratory of Jilin Province for Zoonosis Prevention and Control,Changchun 130062,China

Received:1900-01-01 Revised:2011-05-04 Online:2011-07-20 Published:2011-07-20

Abstract

Abstract: To analyze and predict the structure and characteristics of formyltransferase of Brucella melitensis by bioinformatics in order to guide the experimental research for its biological function and application. Bioinformatics software (DANMAN and Vector NTI),database (prosite and PDB) and net servers were applied to predict and analyse the structures and biochemical properties of formyltransferase of brucella melitensis. Amino acid composition and domain as well as the secondary structures including regions of helix,sheet,turn,coil of the enzyme were well defined. Flexibility,hydrophilicity and surface accessibility which are always used to predict the B-cell epitopes and were simultaneously displayed. These predicted and analytic results could provide data for understanding the relationship between structure and function of the formyltransferase in the pathogenesis and the immunological response.

Key words: Brucella melitensis; formyltransferase; bioinformatics analysis

CLC Number:

Q811.4

WANG Jing-long;WANG Xing-long;. Bioinformatics Analysis of Formyltransferase of Brucella melitensis[J]. China Animal Husbandry & Veterinary Medicine, 2011, 38(7): 123-126.

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Bioinformatics Analysis of Formyltransferase of Brucella melitensis

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