Abstract: 140 KM mice were made experimental Cd poision.LD50 of a Cd was 94.1 mg/kg body weight by acute toxicity test. There were four groups in accumulative toxicity experiment, Ⅰ group, 1/10 LD50（Cd 9.41 mg/kg）, Ⅱ group, 1/5 LD50（Cd 18.82 mg/kg）, Ⅲ group,1/3 LD50（Cd 31.36 mg/kg） and the control group（Cd 0 mg/kg）for 4 weeks. The results showed that body weight in dose groups were much lower than in control group（P<0.05 or P<0.01）.Compared with the control group, the sediment of cadmium in liver, kidney, heart, meat and bone were significant among these groups, especially the sediment of cadmium in liver and kidney. Histopathologicall，the hepatocytes and renaltubular epithelium were degenerate and the spleen gored in dose groups.

Key words: mouse; cadmium; accumulative toxicity