Abstract: Foot-and-mouth disease(FMD) is one of the most highly contagious diseases which affects domestic cloven-hoofed animals.And the disease has debilitating effects, including weight loss, decrease in milk production, and loss of draught power,resulting in a loss in productivity for a considerable time.Current methods of disease control include inhibition of animal movement,slaughter of infected and in-contact susceptible animals,and vaccine inoculation.While current vaccine can induce complete protection by 7~10days, in emergency outbreak situations it is imperative to block or reduce virus shedding as rapidly as possible to contain the outbreak, so some antiviral approach were needed to provide protection for sensitive animals and normal animals during the early of after vaccine inoculation.In this article,progress on antiviral approach of foot-and-mouth disease was reviewed, including IFN,antisense technology and RNA interference.

Key words: foot-and-mouth disease virus; antiviral approach; antisense technology; RNA interference